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Prevalence of Alpha-1 Antitrypsin Dysfunction in Pulmonary Emphysema

Information source: Hospices Civils de Lyon
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Pulmonary Emphysema

Intervention: Blood sampling (Other)

Phase: N/A

Status: Recruiting

Sponsored by: Hospices Civils de Lyon

Overall contact:
Jean-François MORNEX, MD, PhD, Phone: +33 4 72 35 72 89, Email: jean-francois.mornex@chu-lyon.fr

Summary

The main objective of this trial is to evaluate the prevalence of alpha-1 antitrypsin quantitative and functional deficiency in an adult French population presenting with pulmonary emphysema. Phenotypic and genotypic studies will be carried whenever quantitative and/or functional deficiency will be displayed.

Clinical Details

Study design: Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Primary outcome: Number of patient with alpha-1 antitrypsin dysfunction

Secondary outcome:

Determination of alpha-1 antitrypsin protein phenotype

Molecular genotyping of gene coding alpha-1 antitrypsin

Eligibility

Minimum age: 18 Years. Maximum age: 80 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Pulmonary emphysema highlighted by computed tomography

- Ratio Forced Expiratory Volume in 1 second (FEV1) / Vital Capacity (VC) < 70%

measured by lung function test Exclusion Criteria:

- Hepatic transplant

- Patient under legal protection

- Patient not benefiting from the French Health Insurance

Locations and Contacts

Jean-François MORNEX, MD, PhD, Phone: +33 4 72 35 72 89, Email: jean-francois.mornex@chu-lyon.fr

Hôpital Louis Pradel - service de pneumologie, Bron 69677, France; Recruiting
Jean-François MORNEX, MD, PhD, Phone: +33 4 72 35 72 89, Email: jean-francois.mornex@chu-lyon.fr
Bernadette VAZ, CRA, Phone: +33 4 27 85 53 26, Email: Bernadette.vaz@chu-lyon.fr
Jean-François MORNEX, MD, PhD, Principal Investigator
Additional Information

Starting date: December 2014
Last updated: May 26, 2015

Page last updated: August 23, 2015

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