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Active Bathing to Eliminate Infection (ABATE Infection) Trial

Information source: University of California, Irvine
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Healthcare Associated Infections; Methicillin Resistant Staphylococcus Aureus; Multi Drug Resistant Organisms

Intervention: Arm 2: Decolonization (Drug)

Phase: N/A

Status: Active, not recruiting

Sponsored by: University of California, Irvine

Official(s) and/or principal investigator(s):
Susan Huang, MD MPH, Principal Investigator, Affiliation: University of California Irvine School of Medicine
Ken Kleinman, ScD, Study Director, Affiliation: Harvard Medical School/ Harvard Pilgrim Health Care Inst.
Edward Septimus, MD, Study Director, Affiliation: Hospital Corporation of America (HCA)
Jason Hickok, MBA, RN, Study Director, Affiliation: Hospital Corporation of America
Julia Moody, MS, Study Director, Affiliation: Hospital Corporation of America
Mary Hayden, MD, Study Director, Affiliation: Rush University
Robert Weinstein, MD, Study Director, Affiliation: John Stroger Hospital
John Jernigan, MD MS, Study Director, Affiliation: Centers for Disease Control and Prevention
Jonathan Perlin, MD PhD, Study Director, Affiliation: Hospital Corporation of America
Daniel Gillen, PhD, Study Director, Affiliation: University of California, Irvine

Summary

The ABATE Infection Project is a cluster randomized trial of hospitals to compare two quality improvement strategies to reduce multi-drug resistant organisms and healthcare-associated infections in non-critical care units. The two strategies to be evaluated are:

- Arm 1: Routine Care Routine policy for showering/bathing

- Arm 2: Decolonization Use of chlorhexidine as routine soap for showering or bed bathing

for all patients Mupirocin x 5 days if MRSA+ by history, culture, or screen Note that enrolled "subjects" represents 53 individual HCA Hospitals (representing ~190 non-critical care units) that have been randomized.

Clinical Details

Official title: Cluster-Randomized Controlled Trial of Hospitals to Reduce Healthcare-Associated Infections and Readmissions Through Routine Bathing With Antiseptic Soap and Targeted Use of Nasal Antibiotic Ointment (ABATE Infection Trial)

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Health Services Research

Primary outcome: MRSA and VRE clinical cultures

Secondary outcome:

Gram-negative multi-drug resistant organism clinical cultures

All-cause bloodstream infections

Eligibility

Minimum age: 12 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- All HCA hospitals that reside in the United States

- Note: Unit of randomization is the hospital, but the participants are hospital units

Exclusion Criteria:

- Non-critical care units where chlorhexidine bathing or decolonization for MRSA+

non-critical care patients is routine

- Pediatric, peri-partum, rehabilitation, psychiatry, and BMT units

- Units with >30% cardiac or hip/knee orthopedic surgeries

- Unit average length of stay <2 days

- Patients <12 years-old

- Patients with known allergy to mupirocin or chlorhexidine

Locations and Contacts

West Hills Hospital & Medical Center, West HillS, California 91307, United States

North Suburban Medical Center, Thornton, Colorado 80229, United States

Blake Medical Center, Bradenton, Florida 34209, United States

Osceola Regional Medical Center, Kissimmee, Florida 34741, United States

Palms West Hospital, Loxahatchee, Florida 33470, United States

Orange Park Medical Center, Orange Park, Florida 32073, United States

West Florida Hospital, Pensacola, Florida 32514, United States

Northside Hospital, St. Petersburg, Florida 33709, United States

St. Petersburg General Hospital, St. Petersburg, Florida 33710, United States

South Bay Hospital, Sun City Center, Florida 33573, United States

West Palm Hospital, West Palm Beach, Florida 33407, United States

Cartersville Medical Center, Cartersville, Georgia 30120, United States

Coliseum Northside Hospital, Macon, Georgia 31210, United States

Eastside Medical Center, Snellville, Georgia 30078, United States

Overland Park Regional Medical Center, Overland Park, Kansas 66215, United States

Regional Medical Center of Acadiana, Lafayette, Louisiana 70506, United States

Garden Park Medical Center, Gulfport, Mississippi 39503, United States

Research Medical Center, Kansas City, Missouri 64132, United States

Lee's Summit Medical Center, Lee's Summit, Missouri 64063, United States

MountainView Hospital-Las Vegas, Las Vegas, Nevada 89128, United States

Sunrise Hospital and Medical Center, Las Vegas, Nevada 89109, United States

Parkland Medical Center, Derry, New Hampshire 03038, United States

Portsmouth Regional Hospital, Portsmouth, New Hampshire 03801, United States

Colleton Medical Center, Walterboro, South Carolina 29488, United States

Parkridge East Hospital, Chattanooga, Tennessee 37412, United States

Parkridge Medical Center, Chattanooga, Tennessee 37404, United States

TriStar Horizon Medical Center, Dickson, Tennessee 37055, United States

Hendersonville Medical Center, Hendersonville, Tennessee 37075, United States

Summit Medical Center, Hermitage, Tennessee 37076, United States

St. David's Medical Center, Austin, Texas 78705, United States

Valley Regional Medical Center, Brownsville, Texas 78526, United States

Conroe Regional Medical Center, Conroe, Texas 77304, United States

Corpus Christi Medical Center, Corpus Christi, Texas 78411, United States

Las Palmas Medical Center, El Paso, Texas 79902, United States

Plaza Medical Center of Fort Worth, Fort Worth, Texas 76104, United States

Las Colinas Medical Center, Irving, Texas 75039, United States

Kingwood Medical Center, Kingwood, Texas 77339, United States

Northeast Methodist Hospital, Live Oak, Texas 78233, United States

Rio Grande Regional Hospital, McAllen, Texas 78503, United States

North Hills Hospital, North Richland Hills, Texas 76180, United States

Medical Center of Plano, Plano, Texas 75075, United States

Methodist Hospital, San Antonio, Texas 78229, United States

Methodist Specialty and Transplant Hospital, San Antonio, Texas 78229, United States

Methodist Stone Oak Hospital, San Antonio, Texas 78258, United States

Methodist Texsan Hospital, San Antonio, Texas 78201, United States

Clear Lake Regional Medical Center, Webster, Texas 77598, United States

Timpanogos Regional Hospital, Orem, Utah 84057, United States

John Randolph Medical Center, Hopewell, Virginia 23860, United States

LewisGale Hospital-Alleghany, Low Moor, Virginia 24457, United States

Reston Hospital Center, Reston, Virginia 20190, United States

Chippenham Johnston Willis Medical Center, Richmond, Virginia 23225, United States

Henrico Doctors' Hospital, Richmond, Virginia 23229, United States

Additional Information

Starting date: April 2014
Last updated: August 10, 2015

Page last updated: August 23, 2015

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