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Vasodilator-induced Hypovolemia in Living Liver Donors

Information source: Seoul National University Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: CVP and SVV During Living Donor Hepatectomy; Surgical Field Grade (Condition of Surgical Field; Bleeding, Tension of the IVC)

Intervention: vasodilator induced hypovolemia (Procedure)

Phase: N/A

Status: Recruiting

Sponsored by: Seoul National University Hospital

Overall contact:
Chul-Woo Jung, MD, Email: spss@dreamwiz.com

Summary

Induced hypovolemia is known to improve surgical field during living donor hepatectomy. This procedure is conventionally guided by monitoring the central venous pressure (CVP). Stroke volume variation (SVV) is a novel method to substitute with CVP to monitor cardiac preload. The investigators try to evaluate the relationship between CVP and SVV during CVP-guided vasodilator induced hypovolemia (validation study). Then, feasibility of vasodilator induced hypovolemia using the SVV calculated from the validation study will be tested (feasibility study).

Clinical Details

Official title: Vasodilator-induced Hypovolemia in Living Liver Donors: Central Venous Pressure-guided vs Stroke Volume Variation-guided Technique

Study design: Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: target value of SVV

Secondary outcome:

surgical field

use of inotropics

estimated blood loss

Detailed description: This is a 2-phases study. first phase validation study : Evaluation of the relationship between CVP and SVV during CVP-guided vasodilator induced hypovolemia second phase feasibility study : Comparison of the surgical field grade between validation study group(CVP guided group) and feasibility study group(SVV guided group)

Eligibility

Minimum age: 20 Years. Maximum age: 60 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- adult (20-60 yr)

- elective living liver donors

Exclusion Criteria:

- not obtained informed consent

Locations and Contacts

Chul-Woo Jung, MD, Email: spss@dreamwiz.com

Seoul national University Hospital, Seoul 110-744, Korea, Republic of; Recruiting
Jeonghee Cha, Email: Jeonghee.cha@gmail.com
Phone: 82-2-2072-1601
Additional Information

Starting date: January 2014
Last updated: May 27, 2015

Page last updated: August 23, 2015

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