Vasodilator-induced Hypovolemia in Living Liver Donors
Information source: Seoul National University Hospital
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: CVP and SVV During Living Donor Hepatectomy; Surgical Field Grade (Condition of Surgical Field; Bleeding, Tension of the IVC)
Intervention: vasodilator induced hypovolemia (Procedure)
Phase: N/A
Status: Recruiting
Sponsored by: Seoul National University Hospital Overall contact: Chul-Woo Jung, MD, Email: spss@dreamwiz.com
Summary
Induced hypovolemia is known to improve surgical field during living donor hepatectomy. This
procedure is conventionally guided by monitoring the central venous pressure (CVP). Stroke
volume variation (SVV) is a novel method to substitute with CVP to monitor cardiac preload.
The investigators try to evaluate the relationship between CVP and SVV during CVP-guided
vasodilator induced hypovolemia (validation study). Then, feasibility of vasodilator induced
hypovolemia using the SVV calculated from the validation study will be tested (feasibility
study).
Clinical Details
Official title: Vasodilator-induced Hypovolemia in Living Liver Donors: Central Venous Pressure-guided vs Stroke Volume Variation-guided Technique
Study design: Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
Primary outcome: target value of SVV
Secondary outcome: surgical fielduse of inotropics estimated blood loss
Detailed description:
This is a 2-phases study.
first phase validation study : Evaluation of the relationship between CVP and SVV during
CVP-guided vasodilator induced hypovolemia
second phase feasibility study
: Comparison of the surgical field grade between validation study group(CVP guided group)
and feasibility study group(SVV guided group)
Eligibility
Minimum age: 20 Years.
Maximum age: 60 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- adult (20-60 yr)
- elective living liver donors
Exclusion Criteria:
- not obtained informed consent
Locations and Contacts
Chul-Woo Jung, MD, Email: spss@dreamwiz.com
Seoul national University Hospital, Seoul 110-744, Korea, Republic of; Recruiting Jeonghee Cha, Email: Jeonghee.cha@gmail.com Phone: 82-2-2072-1601
Additional Information
Starting date: January 2014
Last updated: May 27, 2015
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