Measurement of Kidney Blood Flow and Oxygen Levels by MRI
Information source: Wake Forest School of Medicine
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Chronic Kidney Disease
Intervention: Furosemide (Drug)
Phase: N/A
Status: Completed
Sponsored by: Wake Forest School of Medicine Official(s) and/or principal investigator(s): Michael Rocco, MD, Principal Investigator, Affiliation: Wake Forest School of Medicine
Summary
Comparison of renal blood flow measurements by PAH clearance and MRI
Clinical Details
Official title: MRI for the Non-invasive Determination of Renal Blood Flow and Renal Oxygenation
Study design: Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Primary outcome: Measurement of Renal Blood Flow of the Kidney by Both the PAH Method and by MRI
Secondary outcome: Measurement of Regional Blood Oxygenation by MRI
Detailed description:
The traditional measurement of renal blood flow in ml/min involves the collection of
multiple blood and urine samples after an infusion of a drug called para-aminohippurate
(PAH) is given. In this study, the investigators determine the ability of MRI to estimate
renal blood flow. The primary hypothesis is that renal blood flow as measured by PAH
clearance is similar to renal blood flow as estimated by MRI. The measurements by PAH
clearance and MRI are both performed on the same day.
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
In this study, the investigators will enroll 16 men and women aged ≥ 18 years with Stage
II - V chronic kidney disease (CKD). In addition, the investigators will enroll 4
subjects with a glomerular filtration rate (GFR) of greater than 60 ml/min who do not have
any evidence of CKD.
Exclusion Criteria:
This study excludes those not suitable for MRI or for the interventional pharmacologic
procedures.
Locations and Contacts
Wake Forest University Health Sciences, Winston-Salem, North Carolina 27157, United States
Additional Information
Starting date: October 2010
Last updated: April 8, 2015
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