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Measurement of Kidney Blood Flow and Oxygen Levels by MRI

Information source: Wake Forest School of Medicine
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Chronic Kidney Disease

Intervention: Furosemide (Drug)

Phase: N/A

Status: Completed

Sponsored by: Wake Forest School of Medicine

Official(s) and/or principal investigator(s):
Michael Rocco, MD, Principal Investigator, Affiliation: Wake Forest School of Medicine

Summary

Comparison of renal blood flow measurements by PAH clearance and MRI

Clinical Details

Official title: MRI for the Non-invasive Determination of Renal Blood Flow and Renal Oxygenation

Study design: Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Primary outcome: Measurement of Renal Blood Flow of the Kidney by Both the PAH Method and by MRI

Secondary outcome: Measurement of Regional Blood Oxygenation by MRI

Detailed description: The traditional measurement of renal blood flow in ml/min involves the collection of multiple blood and urine samples after an infusion of a drug called para-aminohippurate (PAH) is given. In this study, the investigators determine the ability of MRI to estimate renal blood flow. The primary hypothesis is that renal blood flow as measured by PAH clearance is similar to renal blood flow as estimated by MRI. The measurements by PAH clearance and MRI are both performed on the same day.

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria: In this study, the investigators will enroll 16 men and women aged ≥ 18 years with Stage

II - V chronic kidney disease (CKD). In addition, the investigators will enroll 4

subjects with a glomerular filtration rate (GFR) of greater than 60 ml/min who do not have any evidence of CKD. Exclusion Criteria: This study excludes those not suitable for MRI or for the interventional pharmacologic procedures.

Locations and Contacts

Wake Forest University Health Sciences, Winston-Salem, North Carolina 27157, United States
Additional Information

Starting date: October 2010
Last updated: April 8, 2015

Page last updated: August 23, 2015

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