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The Cardiovascular Effects of Air Pollution: the Role of Nitric Oxide

Information source: University of Edinburgh
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Endothelial Dysfunction

Intervention: Forearm Vascular Study (Procedure)

Phase: N/A

Status: Completed

Sponsored by: University of Edinburgh

Official(s) and/or principal investigator(s):
Anders Blomberg, MD PhD, Principal Investigator, Affiliation: Umeå University
David E Newby, PhD FRCP, Principal Investigator, Affiliation: University of Edinburgh

Summary

Exposure to air pollution has been linked to increased cardiorespiratory morbidity and mortality. The exact component of air pollution that mediates this effect is unknown, but the link is strongest for fine combustion derived particulate matter derived from traffic sources. Recently, it has been demonstrated that inhalation of diesel exhaust impairs vascular vasomotor tone and endogenous fibrinolysis. The mechanism underlying these detrimental vascular is unclear, but is thought to be via oxidative stress and altered bioavailability of endogenous nitric oxide. In these studies we plan to elucidate the role of endogenous nitric oxide (NO) in the adverse vascular responses observed following exposure to diesel exhaust.

Clinical Details

Official title: The Cardiovascular Effects of Air Pollution: the Role of Nitric Oxide

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science

Primary outcome: Forearm blood flow as measured by venous occlusion plethysmography during infusion of NOS inhibitors and vasodilators

Secondary outcome:

Plasma nitrite concentrations

Plasma concentrations of t-PA and PAI

Eligibility

Minimum age: 18 Years. Maximum age: 40 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Healthy volunteers

Exclusion Criteria:

- Use of regular medication (except oral contraceptive pill)

- Current smokers

- Significant occupational exposure to air pollution

- Intercurrent illness

Locations and Contacts

Umeå University, Umeå, Sweden
Additional Information

Related publications:

Mills NL, Törnqvist H, Robinson SD, Gonzalez M, Darnley K, MacNee W, Boon NA, Donaldson K, Blomberg A, Sandstrom T, Newby DE. Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis. Circulation. 2005 Dec 20;112(25):3930-6.

Starting date: April 2009
Last updated: October 8, 2009

Page last updated: August 23, 2015

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