The Effect of Doxycycline on Matrix Metalloproteinase Expression and Activity in the Abdominal Aneurysm
Information source: Leiden University Medical Center
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Aortic Aneurysm, Abdominal
Intervention: doxycycline (Drug)
Phase: Phase 2
Status: Completed
Sponsored by: Leiden University Medical Center Official(s) and/or principal investigator(s):
Jan HN Lindeman, MD, PhD, Principal Investigator, Affiliation: Leiden University Medical Center
Summary
The matrix metalloproteinase-9 (MMP-9) is considered to play a central role in abdominal
aortic aneurysm (AAA) initiation. Doxycycline has direct MMP-9 inhibiting properties in
vitro, and it effectively suppresses AAA development in rodents. Observed inhibition of AAA
progression, and contradictory findings in human studies evaluating the effect of doxycycline
therapy on aortic wall MMP-9 suggest that the effects of doxycycline extend beyond MMP-9
inhibition, and that the effect may be dose dependent.
Clinical Details
Official title: The Effect of Doxycycline on Matrix Metalloproteinase Expression and Activity in the Abdominal Aneurysm
Study design: Basic Science, Randomized, Single Blind (Investigator), Dose Comparison, Parallel Assignment, Efficacy Study
Primary outcome: Collagenase mRNA and protein expression
Detailed description:
In this clinical trial, we evaluated the effect of two weeks of low (50 mg/day), medium (100
mg/day) or high dose (300 mg/day) doxycycline versus no medication in patients undergoing
elective AAA repair. The effect of doxycycline treatment on MMP and cysteine proteases, and
their respective inhibitors was evaluated in an integrative approach.
Eligibility
Minimum age: N/A.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Elective open aneurysm repair
Exclusion Criteria:
- Severe kidney and liver dysfunction
Locations and Contacts
Leiden University Medical Center, Leiden 2300RC, Netherlands
Additional Information
Starting date: May 2002
Ending date: August 2005
Last updated: October 2, 2007
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