Coenzyme Q10 and Clomiphene Citrate (CC) for Ovulation Induction in Polycystic Ovary Syndrome
Information source: Mansoura University
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Polycystic Ovary Syndrome
Intervention: Coenzyme Q10 (Drug); clomiphene citrate (Drug)
Phase: N/A
Status: Completed
Sponsored by: Mansoura University
Summary
Objective of the study was to evaluate the effect of combination of oral Coenzyme Q10
(CoQ10), with clomiphene citrate (CC) for ovulation induction in CC-resistant polycystic
ovary syndrome (PCOS).In a prospective controlled randomized trial performed in a university
hospital and private practice setting. One hundred ten infertile women with PCOS resistant
to CC were randomized to either combined CC/CoQ10 (51 patients, 82 cycles) or CC 150 mg/day
alone (50 patients, 71 cycles) for ovulation induction in patients with CC-resistant PCOS.
Main outcome measures: Number of follicles, serum E2, serum P, endometrial thickness,
pregnancy rate (PR) and miscarriage rate.
Clinical Details
Official title: Combined Coenzyme Q10 and Clomiphene Citrate (CC) for Ovulation Induction in CC-resistant Patients With Polycystic Ovary Syndrome
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment
Primary outcome: Number of ovulating patients
Secondary outcome: Number of pregnancies
Detailed description:
No more details
Eligibility
Minimum age: N/A.
Maximum age: N/A.
Gender(s): Female.
Criteria:
Inclusion Criteria:
- Diagnosis of PCOS based on the revised 2003 consensus on diagnostic criteria and
long-term health risks related to PCOS (2003).
- All women were previously treated with 100 mg of CC daily for 5 days per cycle, for
two to three cycles with persistent anovulation or ovulate with very thin endometrium
<5 mm at the time of hCG administration
Exclusion Criteria:
- patients with hyperprolactinaemia,
- hypercorticism and
- thyroid dysfunction.
- patients receiving medications as cholesterol lowering drugs, as statins,
beta-blockers, and tricyclic antidepressants
Locations and Contacts
Mansoura University Hospitals, Mansoura, Dakahlia 35111, Egypt
Additional Information
Starting date: January 2010
Last updated: July 29, 2013
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