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Health Effects of Biodiesel Exhaust Exposure

Information source: UmeŚ University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Vascular Endothelium

Intervention: Forearm venous occlusion plethysmography study (Other)

Phase: N/A

Status: Completed

Sponsored by: UmeŚ University

Official(s) and/or principal investigator(s):
Jenny A Bosson, MD, PhD, Principal Investigator, Affiliation: Umeå University

Summary

Urban air pollution is a major contributor to greenhouse gases and has been shown to increase cardiovascular mortality and morbidity. This century has seen a rebirth of biofuel marketing and research, with biodiesel emerging as one of the strongest contenders within international markets. The pursuit of alternative renewable fuels is incredibly complex and has powered research in agriculture, biotechnology, production, transportation, feedstocks, ecology and biomass manufacturing. In spite of this, health effects have been an almost completely overlooked aspect. The purpose of this study is to investigate whether 100% biodiesel exhaust exposure in healthy volunteers leads to cardiovascular and inflammatory responses. Further investigations into the chemical composition of biodiesel exhaust will also be performed.

Clinical Details

Official title: Cardiovascular Effects of Exposure to 100% Biodiesel Exhaust in Man

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science

Primary outcome: Vascular vasomotor and fibrinolytic function

Secondary outcome:

Respiratory function tests

Effects of exposure on metabolomic markers in plasma

Eligibility

Minimum age: 18 Years. Maximum age: 60 Years. Gender(s): Male.

Criteria:

Inclusion Criteria: Non-smoking, healthy male subjects. All subjects undergo a general health examination and are required to have normal clinical examination, ECG, blood tests and lung function. Exclusion Criteria:

- Diabetes Mellitus

- Cardiovascular disease

- Asthma

- Respiratory infection within 2 weeks of the study

- Antioxidant- and/or vitamin supplementation within 1 week prior to, as well as during

the course of the study. (incl vitamin C, Acetylcysteine)

- Smokers or regular snus usage

Locations and Contacts

Umeå University Hospital, Umeå 90185, Sweden
Additional Information

Starting date: September 2012
Last updated: June 18, 2013

Page last updated: August 23, 2015

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