The Effect of Priming Intravenous Rocuronium on Fentanyl-Induced Coughing
Information source: Taichung Armed Forces General Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Fentanyl-induced Coughing
Intervention: Rocuronium (Drug)
Phase: N/A
Status: Completed
Sponsored by: Taichung Armed Forces General Hospital Official(s) and/or principal investigator(s):
Chih-Shung Wong, PhD, Study Director, Affiliation: Cathay General Hospital
Summary
An intravenous bolus of fentanyl often induces a cough reflex. This study investigates
whether priming with rocuronium can attenuate fentanyl-induced coughing effectively.
Clinical Details
Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Prevention
Primary outcome: Incidence of fentanyl-induced coughing
Detailed description:
Fentanyl is widely used for analgesia and anesthesia because of its rapid onset, its intense
analgesic effect, and is associated with lessened cardiovascular depression and low
histamine release. Although the cough reflex is usually transient and self-limiting, it
should be avoided in situations such as elevated intracranial, intraocular, or
intra-abdominal pressure, and unstable hemodynamics.
The cause of FIC is unclear. One hypothesis is that vocal cord spasms might induce coughing
because of fentanyl-induced muscle rigidity and histamine release. Muscle relaxants are
commonly used to treat this condition. This study hypothesizes that priming muscle relaxants
could prevent or suppress FIC. This study investigates whether the muscle relaxant
rocuronium attenuates FIC effectively.
Eligibility
Minimum age: 18 Years.
Maximum age: 80 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- 260 ASA I-II patients,
- aged between 18 and 80 years, and undergoing various elective surgeries at Taichung
Armed Forces General Hospital.
Exclusion Criteria:
- a history of asthma,
- chronic cough,
- smoking,
- upper respiratory tract infection in the previous 2 weeks, and
- medication containing angiotensin-converting enzyme inhibitors or anesthetic
premedication.
Locations and Contacts
Taichung Armed Forces General Hospital, Taichung 411, Taiwan
Additional Information
Starting date: March 2011
Last updated: February 9, 2012
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