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Nicardipine Versus Labetalol During Intubation

Information source: Seoul National University Bundang Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Patients Who Are Intubated for General Anesthesia; Endotracheal Intubation

Intervention: labetalol (Drug); nicardipine (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: Seoul National University Bundang Hospital

Overall contact:
Jung-Hee Ryu, Ph.D, Phone: 82-31-787-7497, Email: jinaryu@lycos.co.kr


The aim of this study was to compare the efficacy of nicardipine and labetalol in attenuation of cardiovascular responses to endotracheal intubation.

Clinical Details

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Prevention

Primary outcome: hemodynamic variables (systolic blood pressure, diastolic blood pressure and mean blood pressure, heart rate)


Minimum age: 20 Years. Maximum age: 65 Years. Gender(s): Both.


Inclusion Criteria:

- Patients scheduled for general anesthesia with endotracheal intubation

Exclusion Criteria:

- Patients with heart failure or coronary artery disease 2-3 degree atrio-ventricular

block or severe bradycardia (< 45 beats/min) asthma, bronchial spasm or chronic obstructive pulmonary disease patients with anticipated difficult intubation (Mallampati class III, IV) severe hepatic or renal dysfunction allergy or contraindication to study medication

Locations and Contacts

Jung-Hee Ryu, Ph.D, Phone: 82-31-787-7497, Email: jinaryu@lycos.co.kr

Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do 463-707, Korea, Republic of; Recruiting
Jung-Hee Ryu, Ph.D, Phone: 82-31-787-7497, Email: jinaryu@lycos.co.kr
Additional Information

Starting date: September 2009
Last updated: December 30, 2009

Page last updated: August 23, 2015

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