DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Effects of Cox-II Inhibitor on Biochemical Markers in Cardiovascular-related Adverse Effects

Information source: National Chung Hsing University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Arthritis

Phase: N/A

Status: Active, not recruiting

Sponsored by: National Chung Hsing University


The selective cyclooxygenase-2 (COX-2) inhibitors have been associated with increased cardiovascular risk. The goal of the present study is to investigate the impacts of COX-2 inhibitors on biochemical indices in cardiovascular disease. As the reviewer suggested, the investigators propose to study the effects of Cox-II inhibitor using experimentally induced hyperlipidemic rats. Plasma total cholesterol, LDL and triglyceride concentrations will be determined before and after animals treated with cyclooxygenase-2 (COX-2) inhibitors. Biochemical markers related to cardiovascular events including prostaglandin I2, thromboxaneA2 and others will also be investigated. The investigators will also investigate these biochemical markers in patients taking Celecoxib and NSAIDs. The investigators hope these studies will reveal clinically useful biochemical markers for cardiovascular events in patients taking Cox-II inhibitor.

Clinical Details

Study design: Observational Model: Case Control, Time Perspective: Cross-Sectional


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Male/female age >18

- Clinical diagnosed of arthritis

Exclusion Criteria:

- Must not be pregnant/breastfeeding

- Other conditions may lead to exclusion from the trial (e. g. Diabetes mellitus,

malignant melanoma, cardiac conduction disorders, hepatic/renal insufficiency.

Locations and Contacts

Additional Information

Starting date: March 2008
Last updated: July 22, 2009

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017