Comparison Between Recombinant Versus Urinary hCG for Ovulation Induction
Information source: Eugonia
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Infertility
Intervention: ovidrele, pregnyl (Drug)
Phase: Phase 4
Status: Active, not recruiting
Sponsored by: Eugonia
Official(s) and/or principal investigator(s):
Tryfon Lainas, PhD, Principal Investigator, Affiliation: Eugonia
The purpose of this study is to compare the clinical outcomes of recombinant human chorionic
gonadotrophin (rHCG) and urinary HCG (uHCG) in patients undergoing IVF cycles.
Official title: Recombinant hCG (Ovidrel) Vesrus Urinary hCG (Pregnyl) for Ovulation Induction in Normal Responders
Study design: Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Bio-availability Study
Primary outcome: Level of hCG on day of oocyte retrieval
Biochemical pregnancy per embryo transfer
Clinical pregnancy per embryo transfer
Ongoing pregnancy per embryo transfer
Urinary human chorionic gonadotrophin (u-hCG) has been widely used to induce final oocyte
maturation and to trigger ovulation in assisted conception. Recombinant technology has
allowed the production of r-hCG inj which all urinary contaminants are absent. Hence, this
would allow the safe subcutaneous administration of a compound with less batch-to-batch
variation. This study will investigate the effectiveness of the recombinant hCG compared to
the currently used urinary hCG.
Minimum age: 18 Years.
Maximum age: 39 Years.
- BMI 18-29 kg/m2
- Basal FSH <10IU/l
- Basal LH <10 IU/l
- Basal estradiol <80 pg/ml
- Poor responders
Locations and Contacts
Eugonia, Athens 11528, Greece
Revelli A, Poso F, Gennarelli G, Moffa F, Grassi G, Massobrio M. Recombinant versus highly-purified, urinary follicle-stimulating hormone (r-FSH vs. HP-uFSH) in ovulation induction: a prospective, randomized study with cost-minimization analysis. Reprod Biol Endocrinol. 2006 Jul 18;4:38.
Al-Inany HG, Aboulghar M, Mansour R, Proctor M. Recombinant versus urinary human chorionic gonadotrophin for ovulation induction in assisted conception. Cochrane Database Syst Rev. 2005 Apr 18;(2):CD003719. Review.
Starting date: June 2004
Ending date: December 2006
Last updated: January 4, 2007