Desmopressin in Cardiac Surgery
Information source: Università Vita-Salute San Raffaele
Information obtained from ClinicalTrials.gov on November 03, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Hemorrhage; Blood Loss, Surgical; Postoperative Hemorrhage
Intervention: Desmopressin (DDAVP) (Drug)
Phase: Phase 4
Status: Recruiting
Sponsored by: Università Vita-Salute San Raffaele Official(s) and/or principal investigator(s):
Giovanni Landoni, MD, Study Director, Affiliation: Università Vita-Salute San Raffaele, Milano, Italia e Istituto Scientifico San Raffaele, Milano, Italia.
Giuseppe Crescenzi, MD, Principal Investigator, Affiliation: Università Vita-Salute San Raffaele, Milano, Italia e Istituto Scientifico San Raffaele, Milano, Italia.
Overall contact:
giovanni landoni, MD, Phone: +39.347.2520801, Email: landoni.giovanni@hsr.it
Summary
Patients undergoing cardiac surgery could develop excessive perioperative bleeding requiring
transfusions of blood products.
Desmopressin (DDAVP), already used for patients with von Willebrand syndrome, could reduce
bleeding and transfusion requirements in these patients when administered ev (0. 3 mg/kg) in
20-30 minutes postoperatively.
Clinical Details
Official title: Efficacy of Desmopressin (1-deamin0-8-D-Arginine-Vasopressin) in Reducing Active Microvascular Bleeding After Cardiac Surgery
Study design: Prevention, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study
Primary outcome: Reduce transfusions
Secondary outcome: Reduced bleedingReduce time on mechanical ventilation Reduced ICU and Hospital stay Reduced mortality
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- undergoing cardiac surgery
- excessive bleeding
Exclusion Criteria:
- age<18 y
- not signing written consent
Locations and Contacts
giovanni landoni, MD, Phone: +39.347.2520801, Email: landoni.giovanni@hsr.it
Università Vita-Salute San Raffaele, Milano, Italia e Istituto Scientifico San Raffaele, Milano, Italia, Milan 20132, Italy; Recruiting
Istituto Policlinico S.Donato, Milano, Italy; Not yet recruiting
Giuseppe Isgrò, MD, Principal Investigator
Marco Ranucci, MD, Sub-Investigator
Istituto Ospedaliero Fondazione Poliambulanza, Brescia, Italy; Not yet recruiting
Elena Conti, MD, Principal Investigator
Gregorio Finamore, Sub-Investigator
Additional Information
Starting date: June 2006
Ending date: March 2007
Last updated: March 19, 2007
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