Does Caffeine Affect the Sensitivity of Adenosine Perfusion Scans?
Information source: University of Wisconsin, Madison
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Coronary Artery Disease
Intervention: Cardiac SPECT imaging Rest and Stress (Procedure); Caffeine (Drug); Caffeine (Drug)
Sponsored by: University of Wisconsin, Madison
Official(s) and/or principal investigator(s):
Charles K Stone, MD, Principal Investigator, Affiliation: Univeristy of Wisconsin
We are studying the affect of caffeine on the sensitivity of detecting coronary artery
disease (blockages in the blood flow to the heart) with adenosine tracer scans. Adenosine is
a drug used routinely in patients to relax heart blood vessels in order to assess for the
presence of coronary artery disease. Often, if patients have had caffeine, the adenosine
scan is not used because of the belief that caffeine may reduce the ability to detect
coronary artery disease. We would like to test whether caffeine affects our ability to
detect coronary artery disease with adenosine tracer scanning. We will perform an imaging
study of the heart with adenosine after you have received caffeine.
Official title: Does Caffeine Affect the Sensitivity of Adenosine Perfusion Scans?
Study design: Diagnostic, Randomized, Open Label, Active Control, Parallel Assignment
Primary outcome: This protocol has a specific aim of determining whether prior caffeine administration affects the sensitivity and specificity of adenosine perfusion scintigraphy for detection of impaired coronary vascular reserve.
Secondary outcome: determination of caffeine levels in patients instructed to hold caffeine prior to adenosine imaging
Minimum age: 18 Years.
Maximum age: 80 Years.
- Patients who have already completed rest/stress 99mTc sestamibi or 99mTc tetrafosmin
imaging will be given a form describing this protocol and asked to volunteer for the
- history of asthma, bronchospastic COPD, or renal failure
Locations and Contacts
University of Wisconsin, Madison, Wisconsin 53792, United States
Starting date: June 1999
Ending date: December 2008
Last updated: May 16, 2008