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Does Caffeine Affect the Sensitivity of Adenosine Perfusion Scans?

Information source: University of Wisconsin, Madison
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Coronary Artery Disease

Intervention: Cardiac SPECT imaging Rest and Stress (Procedure); Caffeine (Drug); Caffeine (Drug)

Phase: N/A

Status: Completed

Sponsored by: University of Wisconsin, Madison

Official(s) and/or principal investigator(s):
Charles K Stone, MD, Principal Investigator, Affiliation: Univeristy of Wisconsin


We are studying the affect of caffeine on the sensitivity of detecting coronary artery disease (blockages in the blood flow to the heart) with adenosine tracer scans. Adenosine is a drug used routinely in patients to relax heart blood vessels in order to assess for the presence of coronary artery disease. Often, if patients have had caffeine, the adenosine scan is not used because of the belief that caffeine may reduce the ability to detect coronary artery disease. We would like to test whether caffeine affects our ability to detect coronary artery disease with adenosine tracer scanning. We will perform an imaging study of the heart with adenosine after you have received caffeine.

Clinical Details

Official title: Does Caffeine Affect the Sensitivity of Adenosine Perfusion Scans?

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Primary outcome: This protocol has a specific aim of determining whether prior caffeine administration affects the sensitivity and specificity of adenosine perfusion scintigraphy for detection of impaired coronary vascular reserve.

Secondary outcome: determination of caffeine levels in patients instructed to hold caffeine prior to adenosine imaging


Minimum age: 18 Years. Maximum age: 80 Years. Gender(s): Both.


Inclusion Criteria:

- Patients who have already completed rest/stress 99mTc sestamibi or 99mTc tetrofosmin

imaging will be given a form describing this protocol and asked to volunteer for the additional scan Exclusion Criteria:

- history of asthma, bronchospastic COPD, or renal failure

Locations and Contacts

University of Wisconsin, Madison, Wisconsin 53792, United States
Additional Information

Starting date: June 1999
Last updated: October 25, 2012

Page last updated: August 20, 2015

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