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Effects of Brain Stimulation During Daytime Nap on Memory Consolidation in Younger, Healthy Subjects

Information source: Charite University, Berlin, Germany
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Healthy Subjects

Intervention: brain stimulation (Device); no stimulation (Device)

Phase: N/A

Status: Completed

Sponsored by: Charite University, Berlin, Germany

Official(s) and/or principal investigator(s):
Agnes Flöel, Professor, Principal Investigator, Affiliation: Charite Universitätsmedizin Berlin - Neurologie

Summary

The beneficial effect of daytime sleep on memory consolidation has been shown in young, healthy subjects. Especially, periods rich in slow-wave sleep (SWS) have shown a memory enhancing effect on hippocampus-dependent declarative memory. Slow oscillatory activity typically occuring during SWS has been implicated in the consolidation effect. In this study we investigate if the consolidation effect can be amplified by the application of a weak transcranial oscillatory electric current within the frequency range of SWS in humans (0,7-0,8 Hz) during daytime SWS.

Clinical Details

Official title: Impact of Transcranial Slow Oscillating Stimulation on Memory Consolidation During Daytime Slow Wave Sleep in Younger, Healthy Subjects

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Primary outcome: Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS

Secondary outcome:

Amount of Slow wave Sleep

2. sleep spindles

3. EEG-correlates

4. further memory systems

Eligibility

Minimum age: 18 Years. Maximum age: 35 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- healthy Subjects

- unobtrusive, neuropsychological screening

- age: 18-35 years

- right handed

Exclusion Criteria:

- untreated severe internal or psychiatric diseases

- epilepsy

- other severe neurological diseases eg., previous major stroke, brain tumour

- contraindications to MRI

Locations and Contacts

Charite CCM Neurologie Berlin, Berlin 10117, Germany
Additional Information

Related publications:

Marshall L, Helgadóttir H, Mölle M, Born J. Boosting slow oscillations during sleep potentiates memory. Nature. 2006 Nov 30;444(7119):610-3. Epub 2006 Nov 5.

Diekelmann S, Born J. The memory function of sleep. Nat Rev Neurosci. 2010 Feb;11(2):114-26. doi: 10.1038/nrn2762. Epub 2010 Jan 4. Review.

Mednick SC, Cai DJ, Kanady J, Drummond SP. Comparing the benefits of caffeine, naps and placebo on verbal, motor and perceptual memory. Behav Brain Res. 2008 Nov 3;193(1):79-86. doi: 10.1016/j.bbr.2008.04.028. Epub 2008 May 8.

Mander BA, Santhanam S, Saletin JM, Walker MP. Wake deterioration and sleep restoration of human learning. Curr Biol. 2011 Mar 8;21(5):R183-4. doi: 10.1016/j.cub.2011.01.019.

Mednick S, Nakayama K, Stickgold R. Sleep-dependent learning: a nap is as good as a night. Nat Neurosci. 2003 Jul;6(7):697-8.

Starting date: October 2013
Last updated: January 19, 2015

Page last updated: August 23, 2015

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