Use of a Gamma-IFN Assay in Contact Tracing for Tuberculosis in a Low-Incidence, High Immigration Area
Information source: University Hospital, Geneva
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Tuberculosis; Latent Tuberculosis Infection
Phase: N/A
Status: Completed
Sponsored by: University Hospital, Geneva Official(s) and/or principal investigator(s):
Jean-Paul Janssens, M.D., Principal Investigator, Affiliation: Centre antituberculeux
Summary
After exposure to an active case of tuberculosis (TB), close contacts may be infected. They
are then considered as having latent tuberculosis infection (LTBI). Detecting LTBI is the
main goal of contact tracing procedures after exposure to TB. Until recently, the only test
available for detecting LTBI was the tuberculin skin test (TST). More recent tests are now
available (Interferon-gamma release assays: IGRA), which are more specific and sensitive than
the TST. This study compares the TST and an IGRA in the routine activity of contact tracing
in our area.
Clinical Details
Official title: Production of Gamma-Interferon by Circulating Lymphocytes Exposed to Antigens Specific of Mycobacterium Tuberculosis: Contribution to the Identification of Latent Tuberculosis Infection in Contact Tracing
Study design: Case-Only, Prospective
Primary outcome: Correlation between results of TST and IGRA tests and exposure scores
Detailed description:
Setting: A TB clinic in Geneva, Switzerland, a low incidence area for TB with a high
immigrant population.
Aim of study: to compare results of an IGRA test (T-SPOT. TB, Oxford Immunotec, UK) and the
TST, and their correlation with exposure scores in subjects exposed to cases of contagious
TB.
Methods: Prospective study of all contacts screened in our area, and accepting to be
included. Simultaneous recording of age, gender, origin, history of recent travels or
exposure, BCG vaccination status, infectiousness of index case, 5 different exposure scores,
TST, and result of the T-SPOT. TB blood test. Univariate and multivariate analysis.
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Exposure to a case of contagious TB
- Willingness to participate in study
Exclusion Criteria:
- Known HIV infection
- Known previous TB or treatment for LTBI
Locations and Contacts
Centre antituberculeux; Geneva University Hospital, Geneva 1211, Switzerland
Additional Information
Starting date: October 2004
Ending date: January 2006
Last updated: November 13, 2007
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