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Neural Correlates of Stress Hormones

Information source: Charite University, Berlin, Germany
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Borderline Personality Disorder; PTSD

Intervention: Hydrocortisone (Drug); Placebo (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: Charite University, Berlin, Germany


To investigate which neuronal correlates underlie cortisol-induced enhancement of memory retrieval in PTSD and BPD.

Clinical Details

Official title: Why Does Cortisol Enhance Memory Retrieval in Patients With Borderline Personality Disorder and Posttraumatic Stress Disorder? Investigating the Neuronal Correlates of Cortisol Administration and the Effects of Stress Exposure

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science

Primary outcome: brain activation after hydrocortisone

Secondary outcome:

memory retrieval after hydrocortisone

memory retrieval after hydrocortisone

Detailed description: The investigators have recently shown that hydrocortisone enhances rather than impairs memory retrieval in patients with posttraumatic stress disorder (PTSD) and borderline personality disorder (BPD). In contrast, in healthy participants memory retrieval was impaired after hydrocortisone compared to placebo. The proposed studies aim to further investigate these findings and to understand the underlying neuronal correlates. Thus, the mechanisms of enhanced memory retrieval after hydrocortisone in patients with BPD and PTSD will be investigated by fMRI. In a placebo-controlled study, the effects of 10mg hydrocortisone on brain activity, in particular the hippocampus, will be investigated in patients with PTSD and BPD and will be compared with those in healthy control participants. During the fMRI session, a declarative memory task (retrieval of a previous learned word list) and an autobiographical memory test will be performed. Effects of hydrocortisone on resting state brain activity and the neuronal correlates of memory retrieval will be analysed.


Minimum age: 18 Years. Maximum age: 40 Years. Gender(s): Female.


Inclusion Criteria:

- Clinical diagnosis of Borderline Personality Disorder

- Clinical diagnosis of PTSD

- females without psychiatric disorders as control group

- right handed

Exclusion Criteria:

- fMRI exclusion criteria e. g. metal implants, pregnancy, left-handedness, and


Locations and Contacts

Charite University, Berlin, Germany; Recruiting
Katja Wingenfeld, PhD, Phone: 004930450517534, Email: katja.wingenfeld@charite.de
Additional Information

Starting date: January 2014
Last updated: August 13, 2015

Page last updated: August 23, 2015

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