DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Acute Effects of Cortisol on Heroin Craving in Opioid Dependence (Ghost-Basel)

Information source: University of Basel
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Opioid Dependence

Intervention: Cortisol 20 mg (Drug); Mannitol (Drug)

Phase: Phase 2

Status: Completed

Sponsored by: Prof. Dominique de Quervain, MD


To investigate the effects of cortisol on heroin craving and stress reaction in heroin addicted subjects Randomized, double-blind, placebo-controlled, cross-over, single administration of study medication Study hypothesis: Cortisol has an inhibiting effect on heroin craving and stress reactivity in opioid dependent subjects.

Clinical Details

Official title: Acute Effects of Cortisol on Heroin Craving in Opioid Dependence

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Heroin craving

Secondary outcome: Anxiety


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Age ≥ 18

- Opioid dependency

- Participant in the Janus heroin programme of the UPK Basel

- Able to control parallel consumption of other drugs

- Stable i. v. substitution for at least 3 months

Exclusion Criteria:

- co-morbid psychiatric disturbances

- Current medical conditions excluding participation

- Recent history of systemic or topic glucocorticoid therapy

- known hypersensitivity to the IMP under investigation (cor-tisol)

- pregnancy, breast-feeding

- inability to read and understand the participant's information

Locations and Contacts

Psychiatric Hospital, Basel 4012, Switzerland
Additional Information

Starting date: November 2012
Last updated: October 29, 2013

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017