Exercise Induced Asthma and Airway Reactivity in Athletes
Information source: Skåne University Hospital
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Respiratory Function Tests
Phase: N/A
Status: Completed
Sponsored by: Skåne University Hospital Official(s) and/or principal investigator(s): Leif H Bjermer, MD, PhD, Principal Investigator, Affiliation: Lund University
Summary
The overall aim is to explore pathophysiological factors related to airway
hyperresponsiveness to direct and indirect provocation stimuli in athletes with different
sport activities, with special focus on epithelial reaction linked to CC16 and to eicosanoid
related inflammatory response. The investigators also wish to compare indirect testing done
as hyper osmotic challenge with Mannitol compared to a defined sport specific exercise
challenge.
Clinical Details
Official title: Explorative Study "Exercise Induced Asthma and Airway Reactivity in Athletes"
Study design: Time Perspective: Cross-Sectional
Detailed description:
By non-invasive tools the investigators wish to characterize type of airway reaction to
various provocative stimuli in athletes doing two different sort activities, Tennis or
swimming. As controls are being used sedentary age-matched controls from the same region,
exposed to the same school environment. Thus we wish to:
- explore the prevalence of positive mannitol reactivity among swimmers and tennis player
and how this relates to symptoms, disease history and to a sport specific exercise
provocation test.
- compare the results from sport specific testing with a standardized eucapnic
hyperventilation test (EHV)
- compare the overall reactivity to mannitol or EHV among swimmers and tennis players
compared to aged matched controls.
- explore the role by CC16 in airway reactivity to different provocative stimuli and to
see whether there is a difference between different sport activities, different test
protocols and between athletes and controls.
- explore evidence of eicosanoid related inflammatory reaction in athletes and controls
in relation to different provocative stimuli
The study population consists of 100 elite swimmers, 100 elite tennis players and 100
non-elite, eged matched controls. In the latter group, 30 are aged matched non-atopic
non-asthmatic controls.
Eligibility
Minimum age: 16 Years.
Maximum age: 25 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Subjects aged 16-19 from Skåne.
- All should approve attendance in the study by signing an informed consent. Igf they
are aged under 18, parents should also sign.
- Three groups are included
- Elite aspiring swimmers with an average training intensity of at least hours per week
the last year.
Exclusion Criteria:
Locations and Contacts
Additional Information
Starting date: March 2008
Last updated: August 2, 2011
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