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Exercise Induced Asthma and Airway Reactivity in Athletes

Information source: Skåne University Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Respiratory Function Tests

Phase: N/A

Status: Completed

Sponsored by: Skåne University Hospital

Official(s) and/or principal investigator(s):
Leif H Bjermer, MD, PhD, Principal Investigator, Affiliation: Lund University

Summary

The overall aim is to explore pathophysiological factors related to airway hyperresponsiveness to direct and indirect provocation stimuli in athletes with different sport activities, with special focus on epithelial reaction linked to CC16 and to eicosanoid related inflammatory response. The investigators also wish to compare indirect testing done as hyper osmotic challenge with Mannitol compared to a defined sport specific exercise challenge.

Clinical Details

Official title: Explorative Study "Exercise Induced Asthma and Airway Reactivity in Athletes"

Study design: Time Perspective: Cross-Sectional

Detailed description: By non-invasive tools the investigators wish to characterize type of airway reaction to various provocative stimuli in athletes doing two different sort activities, Tennis or swimming. As controls are being used sedentary age-matched controls from the same region, exposed to the same school environment. Thus we wish to:

- explore the prevalence of positive mannitol reactivity among swimmers and tennis player

and how this relates to symptoms, disease history and to a sport specific exercise provocation test.

- compare the results from sport specific testing with a standardized eucapnic

hyperventilation test (EHV)

- compare the overall reactivity to mannitol or EHV among swimmers and tennis players

compared to aged matched controls.

- explore the role by CC16 in airway reactivity to different provocative stimuli and to

see whether there is a difference between different sport activities, different test protocols and between athletes and controls.

- explore evidence of eicosanoid related inflammatory reaction in athletes and controls

in relation to different provocative stimuli The study population consists of 100 elite swimmers, 100 elite tennis players and 100 non-elite, eged matched controls. In the latter group, 30 are aged matched non-atopic non-asthmatic controls.

Eligibility

Minimum age: 16 Years. Maximum age: 25 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Subjects aged 16-19 from Skåne.

- All should approve attendance in the study by signing an informed consent. Igf they

are aged under 18, parents should also sign.

- Three groups are included

- Elite aspiring swimmers with an average training intensity of at least hours per week

the last year. Exclusion Criteria:

Locations and Contacts

Additional Information

Starting date: March 2008
Last updated: August 2, 2011

Page last updated: August 23, 2015

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