Ketamine Associated With Morphine PCA After Total Hip Arthroplasty

Condition(s) targeted: Arthroplasty, Replacement, Hip

Intervention: Ketamine-Morphine (Drug); Morphine (Drug); Postoperative PCA of Ketamine and morphine (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: Assistance Publique - Hôpitaux de Paris

Official(s) and/or principal investigator(s):
Philippe SITBON, MD, Principal Investigator, Affiliation: Assistance Publique - Hôpitaux de Paris Hôpital Bicêtre

Overall contact:
Philippe SITBON, MD, Phone: +33(0)-1 45213447, Email: philippe.sitbon@bct.aphp.fr

Ketamine (an analgesic drug often associated with morphine in the treatment of Opioid Induced Hyperalgesia) is often mixed in Morphine PCA syringe. We make the hypothesis that ketamine administrated separately via a continuous infusion, could induced a better analgesic effect.

We will perform a randomised double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion.

Official title: Impact of the Route of Administration of Ketamine Associated With Morphine PCA on Analgesia After Total Hip Arthroplasty

Study design: Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator), Active Control, Parallel Assignment, Efficacy Study

Primary outcome: Morphine consumption in PACU and in hospitalisation room

Secondary outcome:

Postoperative Visual Analogic Score of pain

Postoperative Measure of mechanical hyperalgesia by Von Frey filament device

Postoperative measure Ketamine and Nor-Ketamine blood levels

Detailed description: Double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- total hip arthroplasty

Exclusion Criteria:

- pre operative opioid administration

Philippe SITBON, MD, Phone: +33(0)-1 45213447, Email: philippe.sitbon@bct.aphp.fr

Service d'anesthesie-reanimation - Hôpital Bicêtre, Le Kremlin Bicêtre 94270, France; Recruiting
Philippe SITBON, MD, Phone: +33(0)-1 4521 3447, Email: philippe.sitbon@bct.aphp.fr

Starting date: November 2008
Ending date: November 2010
Last updated: January 28, 2009