Ketamine Associated With Morphine PCA After Total Hip Arthroplasty
Information source: Assistance Publique - Hôpitaux de Paris
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Arthroplasty, Replacement, Hip
Intervention: Ketamine-Morphine (Drug); Morphine (Drug); Postoperative PCA of Ketamine and morphine (Drug)
Phase: N/A
Status: Completed
Sponsored by: Assistance Publique - Hôpitaux de Paris Official(s) and/or principal investigator(s): Philippe SITBON, MD, Principal Investigator, Affiliation: Assistance Publique - Hôpitaux de Paris Hôpital Bicêtre
Summary
Ketamine (an analgesic drug often associated with morphine in the treatment of Opioid
Induced Hyperalgesia) is often mixed in Morphine PCA syringe. We make the hypothesis that
ketamine administrated separately via a continuous infusion, could induced a better
analgesic effect.
We will perform a randomised double blind study to determine the best infusion mode of
intravenous ketamine, associated with morphine in PCA syringe or alone in continuous
infusion.
Clinical Details
Official title: Impact of the Route of Administration of Ketamine Associated With Morphine PCA on Analgesia After Total Hip Arthroplasty
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
Primary outcome: Morphine consumption in PACU and in hospitalisation room
Secondary outcome: Postoperative Visual Analogic Score of painPostoperative Measure of mechanical hyperalgesia by Von Frey filament device Postoperative measure Ketamine and Nor-Ketamine blood levels
Detailed description:
Double blind study to determine the best infusion mode of intravenous ketamine, associated
with morphine in PCA syringe or alone in continuous infusion
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- total hip arthroplasty
Exclusion Criteria:
- pre operative opioid administration
Locations and Contacts
Service d'anesthesie-reanimation - Hôpital Bicêtre, Le Kremlin Bicêtre 94270, France
Additional Information
Starting date: November 2008
Last updated: April 10, 2013
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