Carbachol´s Headache Inducing Characteristics and Effects on the Cerebral Blood Flow
Information source: Danish Headache Center
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Headache
Intervention: carbachol (Drug)
Phase: N/A
Status: Completed
Sponsored by: Danish Headache Center Official(s) and/or principal investigator(s):
henrik schytz, Principal Investigator, Affiliation: Danish Headache Center
Summary
To investigate headache score and accompanying symptoms during and after infusion of
carbachol.
Clinical Details
Official title: Basic Research on Carbachol´s Headache Inducing Characteristics and Effects on the Cerebral Blood Flow in a Humane Experimental Headache Model
Study design: Screening, Longitudinal, Convenience Sample, Prospective Study
Detailed description:
To investigate headache score and accompanying symptoms during and after infusion of
carbachol.
Changes in regional cerebral blood flow (rCBF) in the area supplied by middle cerebral artery
(MCA), blood flow in MCA, diameter of the superficial temporal artery (STA) and radial
artery (RA)
Eligibility
Minimum age: 18 Years.
Maximum age: 40 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Healthy volunteers
- Aged 18-40
- 50-100 kg
- Fertile women must use safe contraceptives (IUD, oral contraceptives, surgical
sterilisation and long lasting gestagen.
Exclusion Criteria:
- Tension type headache more than once/month
- Other primary headaches
- Daily medication except contraceptives
- Drug taken within 4 times the halflife for the specific drug except contraceptives
- Pregnant or lactating women
- Exposure to radiation within the last year
- Headache within the last 24 hours before start of trial
- Hypertension
- Hypotension
- Respiratory or cardiac disease
Locations and Contacts
Dansih Headache Center, Glostrup 2600, Denmark
Additional Information
Starting date: July 2006
Ending date: April 2007
Last updated: August 29, 2007
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