Valproic Acid, Magnesium Sulphate, Rocuronium Requirement, Postoperative Analgesia
Information source: Seoul National University Bundang Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Cerebral Aneurysm
Intervention: Magnesium Sulfate (Drug); 0.9% saline (Drug); 0.9% saline (Drug)
Phase: N/A
Status: Recruiting
Sponsored by: Seoul National University Bundang Hospital Official(s) and/or principal investigator(s):
Sanghwan Do, Doctor, Study Chair, Affiliation: Seoul National University Bundang Hospital
Overall contact:
Mihyun Kim, Doctor, Phone: 82-31-787-7499, Email: snmd56@yahoo.com
Summary
The investigators hypothesized that valproic acid will increase rocuronium requirement and
MgSO4 infusion would reduce requirement of muscle relaxant in craniotomy patients preloaded
with sodium valproate.
Clinical Details
Official title: Effects of Valproic Acid and Magnesium Sulphate on Rocuronium Requirement and Postoperative Analgesia in Patients Undergoing Craniotomy for Cerebrovascular Surgery
Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary outcome: Rocuronium
Secondary outcome: hemodynamicstotal amount of anesthetics Magnesium concentration side effects pain, nausea & vomiting, analgesics use, antiemetics use, nicardipine use
Detailed description:
Magnesium sulfate (MgSO4) is known to reduce requirement of muscle relaxant.
Eligibility
Minimum age: 18 Years.
Maximum age: 65 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- 18- 65 years
- American society of anesthesiology physical status 1,2
- scheduled for elective craniotomy for aneurysm clipping or for superficial temporal
artery-middle cerebral artery anastomosis
Exclusion Criteria:
body mass index <18. 5 or >24. 9 kg m-2; neuromuscular, renal, cardiovascular or hepatic
insufficiency; Glasgow coma scale (GCS) <15; allergy to the study drugs; medications
influencing NDMRs; breast feeding; pregnancy; and preoperative epilepsy.
Locations and Contacts
Mihyun Kim, Doctor, Phone: 82-31-787-7499, Email: snmd56@yahoo.com
Seoul National University Bundang hopital, Seongnam, Gyeonggi-Do 463-787, Korea, Republic of; Recruiting
Mihyun Kim, Doctor, Phone: 82-31-787-7499, Email: snmd56@yahoo.com
Additional Information
Starting date: October 2011
Last updated: December 26, 2011
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