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Valproic Acid, Magnesium Sulphate, Rocuronium Requirement, Postoperative Analgesia

Information source: Seoul National University Bundang Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Cerebral Aneurysm

Intervention: Magnesium Sulfate (Drug); 0.9% saline (Drug); 0.9% saline (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: Seoul National University Bundang Hospital

Official(s) and/or principal investigator(s):
Sanghwan Do, Doctor, Study Chair, Affiliation: Seoul National University Bundang Hospital

Overall contact:
Mihyun Kim, Doctor, Phone: 82-31-787-7499, Email: snmd56@yahoo.com


The investigators hypothesized that valproic acid will increase rocuronium requirement and MgSO4 infusion would reduce requirement of muscle relaxant in craniotomy patients preloaded with sodium valproate.

Clinical Details

Official title: Effects of Valproic Acid and Magnesium Sulphate on Rocuronium Requirement and Postoperative Analgesia in Patients Undergoing Craniotomy for Cerebrovascular Surgery

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)

Primary outcome: Rocuronium

Secondary outcome:


total amount of anesthetics

Magnesium concentration

side effects

pain, nausea & vomiting, analgesics use, antiemetics use, nicardipine use

Detailed description: Magnesium sulfate (MgSO4) is known to reduce requirement of muscle relaxant.


Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.


Inclusion Criteria:

- 18- 65 years

- American society of anesthesiology physical status 1,2

- scheduled for elective craniotomy for aneurysm clipping or for superficial temporal

artery-middle cerebral artery anastomosis Exclusion Criteria: body mass index <18. 5 or >24. 9 kg m-2; neuromuscular, renal, cardiovascular or hepatic insufficiency; Glasgow coma scale (GCS) <15; allergy to the study drugs; medications influencing NDMRs; breast feeding; pregnancy; and preoperative epilepsy.

Locations and Contacts

Mihyun Kim, Doctor, Phone: 82-31-787-7499, Email: snmd56@yahoo.com

Seoul National University Bundang hopital, Seongnam, Gyeonggi-Do 463-787, Korea, Republic of; Recruiting
Mihyun Kim, Doctor, Phone: 82-31-787-7499, Email: snmd56@yahoo.com
Additional Information

Starting date: October 2011
Last updated: December 26, 2011

Page last updated: August 23, 2015

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