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Study of Blood Lactate Levels in Patients Treated With Antipsychotics

Information source: University of Split
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Movement Disorders; Lactic Acidosis

Intervention: Haloperidol or olanzapine (Drug)

Phase: N/A

Status: Completed

Sponsored by: University of Split

Official(s) and/or principal investigator(s):
Trpimir Glavina, MD, Principal Investigator, Affiliation: University of Split

Summary

Blood lactate levels in patients receiving typical or atypical antipsychotics have not been described in the literature. The goal of this study is to assess the dynamics of lactate levels in the blood from typical or atypical antipsychotics not confounded by prior antipsychotic treatments, the investigators conducted a prospective study of lactate levels in patients receiving antipsychotic medication. The investigators hypothesized that 6 months of treatment with haloperidol or olanzapine would result in a change in blood lactate levels and extrapyramidal side effects.

Clinical Details

Official title: Blood Lactate Levels in Patients Treated With Typical or Atypical Antipsychotics

Study design: Observational Model: Cohort, Time Perspective: Prospective

Primary outcome:

Blood lactate levels

Blood lactate levels

Blood lactate levels

Secondary outcome:

Extrapyramidal side effects

Extrapyramidal side effects

Extrapyramidal side effects

Detailed description: The aim of this study was to compare the blood lactate levels in patients receiving typical or atypical antipsychotics. Subjects included sixty patients with psychotic disorder were assigned to treatment for 6 months with haloperidol (typical antipsychotic), N=30 or olanzapine (atypical antipsychotic), N=30. Blood lactate levels, other metabolic parameters, and scores on the extrapyramidal symptom rating scale (ESRS) were assessed.

Eligibility

Minimum age: 20 Years. Maximum age: 50 Years. Gender(s): Male.

Criteria:

Inclusion Criteria:

- Men aged 20 - 50 years

- Not taking any antipsychotic medication 1 month prior to the study

- Diagnosed psychotic disorder

Exclusion Criteria:

- Female

- Tobacco use

- Diabetes mellitus

- Baseline lactate blood level over 2. 0 mmol/L

Locations and Contacts

Split Clinical Hospital Center, Split 21000, Croatia
Additional Information

Starting date: June 2008
Last updated: June 7, 2010

Page last updated: August 23, 2015

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