Simvastatin Effect on End Stage Renal Failure Patients Treated by Peritoneal Dialysis
Information source: Federal University of São Paulo
Information obtained from ClinicalTrials.gov on November 03, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Renal Failure, End Stage; Peritoneal Dialysis
Intervention: Simvastatin (Drug)
Phase: Phase 4
Status: Recruiting
Sponsored by: Federal University of São Paulo Official(s) and/or principal investigator(s):
Maristela Bohlke, master, Principal Investigator, Affiliation: Federal University of São Paulo
Overall contact:
Maristela Bohlke, MD, Phone: 55 53 32264098, Email: mbohlke@conesul.com.br
Summary
This study will analyse the effect of simvastatin on endothelium dependent venodilation in
chronic renal failure patients treated by peritoneal dialysis. The hypothesis is that
patients will have a greater endothelium dependent venodilation after four months of
simvastatin use.
Clinical Details
Official title: Simvastatin Effect on Endothelium Dependent Venodilation in Chronic Renal Failure Patients Treated by Peritoneal Dialysis
Study design: Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study
Primary outcome: endothelial venodilation
Secondary outcome: Inflammation markers (C-reactive protein, IL-6, TNF)Lipoproteins Oxidative stress
Detailed description:
This study will analyse the effect of simvastatin on endothelium dependent venodilation in
chronic renal failure patients treated by peritoneal dialysis. The hypothesis is that
patients will have a greater endothelium dependent venodilation after four months of
simvastatin use.
Eligibility
Minimum age: 18 Years.
Maximum age: 80 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- end stage renal failure
- peritoneal dialysis
- LDL cholesterol > 100mg/dL
- > 18 years and < 80 years
Exclusion Criteria:
- using statin or nitrate
- liver disease
- diabetes mellitus
Locations and Contacts
Maristela Bohlke, MD, Phone: 55 53 32264098, Email: mbohlke@conesul.com.br
São Lucas Hospital, Porto Alegre, Rio Grande do Sul, Brazil; Recruiting
Carlos Eduardo P Figueiredo, PhD, Principal Investigator
Additional Information
Starting date: February 2006
Ending date: February 2006
Last updated: February 15, 2006
|
