Assessment of Hepatitis B Virus Intra-host Population and Host-specific Immune Marker Diversity
Information source: Universitaire Ziekenhuizen Leuven
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Hepatitis B; Hepatitis B, Chronic; End Stage Liver Disease; Carcinoma, Hepatocellular
Phase: N/A
Status: Enrolling by invitation
Sponsored by: Universitaire Ziekenhuizen Leuven Official(s) and/or principal investigator(s):
MahmoudReza Pourkarim, PhD, Principal Investigator, Affiliation: UZ Leuven campus Gasthuisberg, Herestraat 49. 3000 Leuven, Belgium
Summary
In this project proposal, the investigators will investigate the genetic alterations of
Hepatitis B Virus (HBV) strains circulating in Belgian patients who developed end stage
liver disease. Additionally, the investigators will compare and link these data sets with
three genetic factors involved in immune system response.
Clinical Details
Official title: Assessment of Hepatitis B Virus Intra-host Population and Host-specific Immune Marker Diversity With Next-generation Sequencing: From Chronic Infection to End-stage Liver Disease and Liver Cancer
Study design: Time Perspective: Prospective
Primary outcome: genetic variants of Hepatitis B
Secondary outcome: genetic variation in host-specific immune markers
Detailed description:
This project proposes to identify and characterize the genetic alterations associated with
intra-host evolution of HBV from a chronically infection status to an end-stage liver
disease status.
Eligibility
Minimum age: N/A.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
Study group:
- Clinical diagnosis of advanced liver disease related to chronic Hepatitis B infection
(cirrhosis, hepatocellular carcinoma,..)
- Availability of serum samples
Control group:
- Clinical diagnosis of liver disease related to chronic Hepatitis B infection in a
pre-advanced stage
- Matched demographic and geographic characteristics to study group
- Availability of serum samples
Exclusion Criteria:
- Liver disease caused by other hepato-tropic viruses
- Patients with auto-immune diseases
Locations and Contacts
University Hospitals Leuven campus Gasthuisberg, Leuven, Flemish Brabant 3000, Belgium
Additional Information
Starting date: April 2014
Last updated: May 22, 2014
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