ASA- and Clopidogrel-Responsiveness in Patients With Peripheral Arterial Occlusive Disease and Interventional Procedures
Information source: Johann Wolfgang Goethe University Hospitals
Information obtained from ClinicalTrials.gov on November 03, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Peripheral Arterial Occlusive Disease
Phase: N/A
Status: Recruiting
Sponsored by: Johann Wolfgang Goethe University Hospitals Official(s) and/or principal investigator(s):
Birgit Linnemann, MD, Principal Investigator, Affiliation: Division of Vascular Medicine, Department of Internal Medicine, J.W. Goethe University Hospital Frankfurt
Summary
The purpose of the study is to determine the response to aspirin (ASA) and Clopidogrel in
patients with peripheral arterial occlusive disease (PAOD) requiring interventional
procedures and to investigate if patients with "resistance" to ASA or Clopidogrel have an
unfavourable outcome during long-term follow-up
Clinical Details
Official title: Investigation of Laboratory Resistance to Aspirin and Clopidogrel and Its Clinical Relevance in Patients With Peripheral Arterial Occlusive Disease Requiring Interventional Procedures
Study design: Cohort, Prospective
Primary outcome: Need for peripheral arterial revascularisation
Secondary outcome: Cardiovascular events (death, myocardial infarction, stroke, ACS, PCI)
Eligibility
Minimum age: 18 Years.
Maximum age: 85 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- PAOD patients
- Age 18-85 years
- Need for a catheter interventional procedure
- Antithrombotic therapy with aspirin or clopidogrel
Exclusion Criteria:
- Comedication additionally compromising platelet function
- Known bleeding disorder
- Life expectancy < 6 months
Locations and Contacts
Division of Vascular Medicine, Department of Internal Medicine, J.W.Goethe University Hospital, Frankfurt/Main, Hessen D-60590, Germany; Recruiting
Birgit Linnemann, MD, Phone: +49 69 6301 5096, Email: Birgit.Linnemann@kgu.de
Additional Information
Starting date: May 2005
Ending date: December 2009
Last updated: January 14, 2008
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