The Effect of Testosterone on Mood and Quality of Life

Condition(s) targeted: Gonadal Disorders; Depressive Disorder; Hypogonadism

Intervention: Testosterone or placebo gel (Drug)

Phase: Phase 4

Status: Active, not recruiting

Sponsored by: Seattle Institute for Biomedical and Clinical Research

Official(s) and/or principal investigator(s):
Molly M Shores, MD, Principal Investigator, Affiliation: University of Washington VA Puget Sound Health Care System, GRECC

We hypothesize that testosterone replacement will improve mood and quality of life in older men with low testosterone and mild depression. Study subjects will receive either testosterone gel or a placebo (inactive) gel for 12 weeks. Neither the subject or the investigator will know whether they are receiving placebo or testosterone gel. At the end of the initial 12 week period, all subjects will receive testosterone gel for 12 more weeks. Mood and quality of life measures will be obtained at baseline and every 6 weeks over the course of the study.

Official title: The Effect of Testosterone Treatment on Depressive Symptoms and Quality of Life in Older Men With Age-Related Hypogonadism and Subsyndromal Depression.

Study design: Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study

Primary outcome: Hamilton Depression Rating Scale

Secondary outcome:

SF-36

Endicott Quality of Life Scale

SCL-20

Detailed description: This is a randomized, double-blind, placebo-controlled trial of testosterone replacement in older men with age-associated hypogonadism and subsyndromal depression. Men will receive either 7. 5 gm/qd of testosterone gel or a placebo gel for 12 weeks. The double-blind phase will be followed by a 12 week open-label extension in which all subjects will receive 7. 5 gm/qd of testosterone gel.

Procedures: Depressive symptoms will be assessed with the Hamilton Depression Rating Scale (HDRS) and the SCL-20, a 20-item self-report depression scale that has been shown to have high reliability and validity and to be sensitive to changes in depressive symptoms in outpatients in primary care settings. The short form (16 item) Endicott Quality of Life Enjoyment and Satisfaction Scale will be used to assess quality of life changes. The Medical Outcomes Study Short-Form 36 (SF-36) will be used to assess changes in functional status. Demographic information, medical history and current medications will be determined at baseline and follow up, via patient interview and chart review. Overall medical morbidity will be ascertained with the Cumulative Illness Rating Scale. All outcome measures (SCL-20, Endicott Quality of Life Scale, HDRS,SF-36) will be assessed at baseline, week 6 and week 12 of the double-blind phase and week 18 and week 24 of the extension phase. Blood draws will be done at baseline, week 12 and week 24. Laboratory assays for baseline, week 12 and week 24 will be performed at the same time to minimize interassay variability.

Minimum age: 50 Years. Maximum age: N/A. Gender(s): Male.

Criteria:

Inclusion Criteria:

- Age: 50 or older

- Total Testosterone <=280 ng/dl

- Subsyndromal depressive disorder with a Hamilton Depression Score of >10.

Exclusion Criteria:

- PSA >=4. 0

- Klinefelter's syndrome

- Prostate or breast cancer

- Hospitalized in the past month

- Obstructive BPH

- Current testosterone treatment

- Alcohol dependence

- Suicidal or psychotic symptoms

Starting date: November 2002
Ending date: January 2006
Last updated: September 22, 2006