Morphine Analgesia in Patients With Acute Appendicitis
Information source: Tehran University of Medical Sciences
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Appendicitis
Intervention: Morphine (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: Tehran University of Medical Sciences Official(s) and/or principal investigator(s):
Asieh Golozar, MD, Principal Investigator, Affiliation: Tehran University of Medical Sciences
Summary
The purpose of the study is to evaluate morphine effect on pain reduction and diagnostic
accuracy in patients admitted to emergency ward with the diagnosis of acute appendicitis.
Clinical Details
Official title: Double Blind Randomized Study of Morphine Analgesia in Patients With Acute Appendicitis
Study design: Supportive Care, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study
Primary outcome: Pain Intensity
Secondary outcome: Diagnostic Accuracy
Detailed description:
Analgesic administration for pain control in patients with acute abdominal pain, regarding
acute appendicitis, is controversial. Despite the results previous studies indicating the
safeness of analgesic use in ED for acute abdominal pain, physicians still prefer to postpone
their use after performing surgical evaluations. Since many patients admitted to ED are
unlikely to receive prompt surgical consultation, many of them need pain relief to prevent
unnecessary suffering. On the other hand such pain relief must not interfere with the
diagnosis and treatment of patients and do not cause any complications. Morphine is a common
and effective analgesic which, if shown to have no effect on correct diagnosis of acute
abdomen, can be used for this purpose.
Thus we evaluated morphine effect on pain reduction and diagnostic accuracy in patients
admitted to ED with the diagnosis of acute appendicitis.
Eligibility
Minimum age: 13 Years.
Maximum age: 75 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- clinical signs of acute appendicitis
- planned for appendectomy
- supposed to wait for at least 1 hour in the ED before operation
Exclusion Criteria:
- suspicion to perforated appendicitis
- being under the age of 13
- pregnancy (according to history and ß-HCG result)
- opium addiction
- systolic blood pressure of less than 90 mmHG
- known cases of chronic obstructive pulmonary disease (COPD)
- known sensitivity to morphine
- history of sickle cell disease
- self administration of analgesics before enrollment
- refusal to participate
Locations and Contacts
Sina General Hospital, Tehran, Iran, Islamic Republic of
Additional Information
Starting date: January 2004
Ending date: March 2005
Last updated: May 20, 2007
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