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A Pharmacokinetic and Pharmacogenetic Study in Patients Receiving Sulfamethoxazole-trimethoprim Therapy

Information source: National Taiwan University Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Pneumocystis Jirovecii Pneumonia

Phase: N/A

Status: Recruiting

Sponsored by: National Taiwan University Hospital

Overall contact:
Jin-Han Yang, Bachelor, Phone: 0975-103-277, Email: r01451004@ntu.edu.tw

Summary

In this study, we aim to investigate the incidence of the adverse reactions, the effectiveness and the gene polymorphism associated with the plasma level of sulfamethoxazole-trimethoprim and their metabolites (including N4-acetyl-sulfamethoxazole, sulfamethoxazole hydroxylamine and sulfamethoxazole-nitroso). And we also aim to investigate the factors associated with the sulfamethoxazole-trimethoprim induced acute psychosis.

Clinical Details

Official title: A Pharmacokinetic and Pharmacogenetic Study in Patients Receiving Sulfamethoxazole-trimethoprim Therapy

Study design: Observational Model: Case-Only, Time Perspective: Prospective

Primary outcome: High performance liquid chromatography for drug plasma concentration

Eligibility

Minimum age: 20 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- males and females aged 20 years or older

- using oral or intravenous form of sulfamethoxazole-trimethoprim

Exclusion Criteria:

- patients who are under 20 years of age

Locations and Contacts

Jin-Han Yang, Bachelor, Phone: 0975-103-277, Email: r01451004@ntu.edu.tw

National Taiwan University Hospital, Taipei, TW 106, Taiwan; Active, not recruiting

National Taiwan University Hospital, Taipei, TW 106, Taiwan; Recruiting
Jin-Han Yang, Email: r01451004@ntu.edu.tw
Shu-Wen Lin, Principal Investigator

Additional Information

Starting date: January 2014
Last updated: July 31, 2014

Page last updated: August 23, 2015

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