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Peri-operative Oral Triiodothyronine Replacement Therapy to Decrease the Risk of Transient Atrial Fibrillation After Off-pump Coronary Artery Bypass Surgery

Information source: Yonsei University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Non-thyroidal Illness Syndrome

Intervention: liothyronine sodium (Drug); placebo (Drug)

Phase: N/A

Status: Completed

Sponsored by: Yonsei University

Official(s) and/or principal investigator(s):
Yong-Sun Choi, MD, Ph.D, Principal Investigator, Affiliation: Anesthesiology & Pain Medicine, Severance Hospital

Summary

This study is planned to medicate oral T3(Liothyronine)to the patients who are planned to have OPCAB(off- pump coronary bypass graft surgery. The aim of this study was to assess the effects of oral triiodothyronine (T3) therapy on postoperative thyroid hormone concentrations, hemodynamic variables and outcomes in patients undergoing OPCAB in a randomized, controlled trial.

Clinical Details

Official title: Peri-operative Oral Triiodothyronine Replacement Therapy to Decrease the Risk of Transient Atrial Fibrillation After Off-pump Coronary Artery Bypass Surgery

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Supportive Care

Primary outcome: compare the serum T3 concentrations and the number of patients with serum T3 concentrations below the normal range between the groups

Secondary outcome: difference of hemodynamic performance and myocardial injury

Eligibility

Minimum age: 20 Years. Maximum age: 75 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patients who are undergoing Off-pump coronary artery bypass graft

Exclusion Criteria:

- No normal sinus rhythm,

- History of thyroid disease

- Abnormal thyroid hormone

- Renal dysfunction

- Hepatic dysfunction

- LVEF <30%

- Recent MI

- Active infection 1~15

Locations and Contacts

Severance Hospital, Seoul, Korea, Republic of
Additional Information

Starting date: June 2010
Last updated: July 23, 2012

Page last updated: August 23, 2015

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