Peri-operative Oral Triiodothyronine Replacement Therapy to Decrease the Risk of Transient Atrial Fibrillation After Off-pump Coronary Artery Bypass Surgery
Information source: Yonsei University
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Non-thyroidal Illness Syndrome
Intervention: liothyronine sodium (Drug); placebo (Drug)
Phase: N/A
Status: Completed
Sponsored by: Yonsei University Official(s) and/or principal investigator(s): Yong-Sun Choi, MD, Ph.D, Principal Investigator, Affiliation: Anesthesiology & Pain Medicine, Severance Hospital
Summary
This study is planned to medicate oral T3(Liothyronine)to the patients who are planned to
have OPCAB(off- pump coronary bypass graft surgery. The aim of this study was to assess the
effects of oral triiodothyronine (T3) therapy on postoperative thyroid hormone
concentrations, hemodynamic variables and outcomes in patients undergoing OPCAB in a
randomized, controlled trial.
Clinical Details
Official title: Peri-operative Oral Triiodothyronine Replacement Therapy to Decrease the Risk of Transient Atrial Fibrillation After Off-pump Coronary Artery Bypass Surgery
Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Supportive Care
Primary outcome: compare the serum T3 concentrations and the number of patients with serum T3 concentrations below the normal range between the groups
Secondary outcome: difference of hemodynamic performance and myocardial injury
Eligibility
Minimum age: 20 Years.
Maximum age: 75 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Patients who are undergoing Off-pump coronary artery bypass graft
Exclusion Criteria:
- No normal sinus rhythm,
- History of thyroid disease
- Abnormal thyroid hormone
- Renal dysfunction
- Hepatic dysfunction
- LVEF <30%
- Recent MI
- Active infection 1~15
Locations and Contacts
Severance Hospital, Seoul, Korea, Republic of
Additional Information
Starting date: June 2010
Last updated: July 23, 2012
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