This study aims to examine the safety, tolerability and pharmacokinetics of transdermal
delivery of human Growth Hormone (hGH or somatropin) using the ViaDerm device in adult
patients with Growth Hormone Deficiency Syndrome.
Inclusion Criteria:
Ages Eligible for Study: 20 Years - 60 Years, Genders Eligible for Study: Both
1. Clinical diagnosis of Adult Growth Hormone Deficiency (AGHD) meeting one of the
following criteria:
- Three or more additional pituitary hormone deficiencies, based on well documented
medical history from up to 10 years prior to screening, and/or serum IGF-1 levels
below 2 SD from normal level, measured up to 4 months prior to screening.
- One or two additional pituitary hormone deficiencies with one GH stimulating test
performed within 10 years prior to screening: Insulin Tolerance test with GH
levels less than 5. 1 µg/L or ARG-GHRH with GH levels less than 4. 1 µg/L.
- Isolated GH deficient subjects with two well-documented GH stimulating tests
performed within 10 years prior to screening. Insulin Tolerance test with GH
levels less than 5. 1 µg/L or ARG-GHRH with GH levels less than 4. 1 µg/L.
- In childhood onset AGHD, confirmation of GHD following attainment of full
height.
2. Subjects using hormone replacement therapy for additional pituitary deficits must be
on an optimized treatment regimen for at least three months prior to screening.
3. Willing and able to provide written informed consent prior to performing any study
procedures.
Exclusion Criteria:
1. GH therapy within one month prior to study entry.
2. For female subjects: pregnancy or lactation or use of oral contraception or
unacceptable method of contraception throughout the study.
3. Active acromegaly in the last 5 years.
4. Carpal tunnel syndrome.
5. Prader-Willi syndrome.
6. Active Cushing's syndrome within the last 12 months.
7. Non-compliance for upper arm SC injection or patch application.
8. Skin color or tattoo that would not enable detection of erythema.
9. Upper extremities with skin marks, bruises, cuts, abrasions on the upper arm.
10. Dense and dark hair growth on upper extremities.
11. History of skin hypersensitivity and/or allergies.
12. Known hypersensitivity to somatropin or mannitol
13. Evidence of active malignancy.
14. Previous use of chemotherapy, immunosuppressive or radiation therapy, except for
treatment of pituitary disease.
15. Serum glucose (fasting) > 126 mg/dl.
16. Known or suspected HIV-positive subjects or subjects with advanced diseases such as
AIDS, Hepatitis C, Hepatitis B or tuberculosis.
17. Subjects who, based on the investigator's judgment, have a clinically significant or
unstable medical or surgical condition that may preclude safe and complete study
participation. Conditions may include cardiovascular, vascular, pulmonary, hepatic,
renal, or neurological disease, as determined by medical history, physical
examination, laboratory tests or ECG.
18. BMI < 19 and ≥ 35 kg/m2.
19. Weight reducing drugs or appetite suppressants.
20. Estrogen replacement therapy except transdermal patch.
21. Any psychological condition which may influence the compliance with the study
requirements.
22. Unstabilized antidepressant or antipsychotic medication therapy within 2 months prior
to screening.
23. Subjects with a known history of alcohol abuse.
24. Subjects who received blood or plasma derivatives in the three months preceding
screening.
25. Subjects who donated blood in the preceding three months of screening or intend to
make a blood donation during the study, or within the three months following the study
completion.
26. Subjects who have participated in another clinical study of any kind (drug or device)
in the one month prior to screening.
27. Subjects who, in the judgment of the investigator, are likely to be non-compliant or
uncooperative during the study.
