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Topical Hydromorphone for Wound Healing

Information source: University of Minnesota - Clinical and Translational Science Institute
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Wound Healing

Intervention: hydromorphone (Drug)

Phase: Phase 1/Phase 2

Status: Terminated

Sponsored by: Hordinsky, Maria K., MD

Official(s) and/or principal investigator(s):
Maria Hordinsky, MD, Principal Investigator, Affiliation: University of Minnesota - Clinical and Translational Science Institute
Robert Hebbel, MD, Principal Investigator, Affiliation: University of Minnesota - Clinical and Translational Science Institute

Summary

The hypothesis is that topical opioids will hasten wound healing in humans.

Clinical Details

Official title: Topical Hydromorphone for Wound Healing

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind, Primary Purpose: Treatment

Primary outcome: Healing rates and microvessel density will be compared statistically for the control-ointment versus hydromorphone-ointment subjects.

Detailed description: This is based on our published data that morphine is a powerful stimulant of angiogenesis and our preclinical study of wounds in rats which demonstrate that topical opioids (morphine, hydromorphone and fentanyl) hasten healing of punch biopsy wounds. This study will focus on hydromorphone which was more powerful than morphine as a wound-healer in the rat study.

Eligibility

Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Self-identified as normal, healthy volunteers age 18-65.

Exclusion Criteria:

- Known bleeding disorder.

Locations and Contacts

University of Minnesota, Minneapolis, Minnesota 55455, United States
Additional Information

Starting date: October 2003
Last updated: February 26, 2010

Page last updated: August 23, 2015

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