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Central Hypothyroidism and Cardiovascular Risk

Information source: Rigshospitalet, Denmark
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Hypopituitarism

Intervention: levothyroxine (Other)

Phase: N/A

Status: Completed

Sponsored by: Rigshospitalet, Denmark

Official(s) and/or principal investigator(s):
Ulla Feldt-Rasmussen, Professor, Principal Investigator, Affiliation: Rigshospitalet, Denmark

Summary

Retrospective trial of 300 patients with pituitary insufficiency treated in Department of Medica Endocrinology, Rigshospitalet, Copenhagen University concerning levothyroxine (T4) replacement and cardiovascular risk factors. The hypothesis is that subtle central hypothyroidism is associated with adverse cardiac risk factors, such as body composition and serum lipids, and that improved T4 replacement will eliminate this increased risk, independently of other pituitary hormone replacements.

Clinical Details

Official title: Central Hypothyroidism and Cardiovascular Risk Factors

Study design: Observational Model: Cohort, Time Perspective: Retrospective

Primary outcome: cholesterol

Detailed description: Retrospective trial of 300 patients with pituitary insufficiency treated in Department of Medical Endocrinology, Rigshospitalet, Copenhagen University concerning levothyroxine (T4) replacement and cardiovascular risk profile. The patient files are recruited among hypopituitary patients treated with growth hormone from the period 1993 to 2008. The trial is a retrospective assessment of data already collected for routine purposes and thus an audit of daily clinical practice. All information on the patients is obtained from the paper and electronic files existing in the department and no new measurements are foreseen.

Eligibility

Minimum age: N/A. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- All patients with pituitary hypopituitarism

Exclusion Criteria:

- Unavailability of data

Locations and Contacts

Rigshospitalet, Copenhagen 2100, Denmark
Additional Information

Starting date: April 2012
Last updated: March 30, 2013

Page last updated: August 23, 2015

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