Central Hypothyroidism and Cardiovascular Risk
Information source: Rigshospitalet, Denmark
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Hypopituitarism
Intervention: levothyroxine (Other)
Phase: N/A
Status: Completed
Sponsored by: Rigshospitalet, Denmark Official(s) and/or principal investigator(s): Ulla Feldt-Rasmussen, Professor, Principal Investigator, Affiliation: Rigshospitalet, Denmark
Summary
Retrospective trial of 300 patients with pituitary insufficiency treated in Department of
Medica Endocrinology, Rigshospitalet, Copenhagen University concerning levothyroxine (T4)
replacement and cardiovascular risk factors. The hypothesis is that subtle central
hypothyroidism is associated with adverse cardiac risk factors, such as body composition and
serum lipids, and that improved T4 replacement will eliminate this increased risk,
independently of other pituitary hormone replacements.
Clinical Details
Official title: Central Hypothyroidism and Cardiovascular Risk Factors
Study design: Observational Model: Cohort, Time Perspective: Retrospective
Primary outcome: cholesterol
Detailed description:
Retrospective trial of 300 patients with pituitary insufficiency treated in Department of
Medical Endocrinology, Rigshospitalet, Copenhagen University concerning levothyroxine (T4)
replacement and cardiovascular risk profile. The patient files are recruited among
hypopituitary patients treated with growth hormone from the period 1993 to 2008. The trial
is a retrospective assessment of data already collected for routine purposes and thus an
audit of daily clinical practice. All information on the patients is obtained from the paper
and electronic files existing in the department and no new measurements are foreseen.
Eligibility
Minimum age: N/A.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- All patients with pituitary hypopituitarism
Exclusion Criteria:
- Unavailability of data
Locations and Contacts
Rigshospitalet, Copenhagen 2100, Denmark
Additional Information
Starting date: April 2012
Last updated: March 30, 2013
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