Prediction of Antidepressant Response Using Pharmacogenetics and Peripheral Lymphocytic Phenotype
Information source: Samsung Medical Center
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Depression
Intervention: responders (Drug); non-responders (Drug)
Phase: N/A
Status: Active, not recruiting
Sponsored by: Samsung Medical Center Official(s) and/or principal investigator(s): Doh Kwan Kim, M.D., Ph.D., Principal Investigator, Affiliation: Samsung Medical Center
Summary
The purpose of this study is to determine whether pharmacogenomic study of bioamine
transporters and peripheral lymphatic biomarkers(phenotype) predict antidepressant
responsiveness in advance before the appearance of the drug effects until 4~6 weeks after
drug administration.
Clinical Details
Official title: Prediction of Antidepressant Response Using Pharmacogenetics of Bioamine Transporter and Peripheral Lymphocytic Phenotype
Study design: Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Treatment
Primary outcome: Antidepressant Response at 6 weeks
Secondary outcome: Biological value at 0 and 6 weeks
Detailed description:
The purpose of this study is to determine whether genomic effects or peripheral lymphatic
biomarkers on antidepressant response differed by class of drug, whether genomic and
biomarker differences between drug responders and nonresponders predict the response of
antidepressant and to construct the prediction model for antidepressant treatment in order
to aid to select the their genetically or endophenotypic matching drugs.
Eligibility
Minimum age: 19 Years.
Maximum age: 89 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
1. eligible patients were enrolled in the clinical trials program of hte Samsung Medical
Center Geropsychiatry and Affective Disorder Clinics(Seoul, Korea). They received a
semistructured diagnostic interview, the Samsung Psychiatric Evaluation Schedule. The
affective disorder section of the Samsung Psychiatric Evaluation Schedule uses the
Korean version of the structured clinical interview for the diagnostic and
statistical manual of mental disorders, Fourth edition.
2. interview with one more patient's family member for objective diagnosis and final
diagnosis decision by agreements of two more psychiatric physicians
Exclusion Criteria:
1. received psychotropic medication within 2 weeks of the study or fluoxetine within 4
weeks
2. potential study participants for pregnancy, significant medical conditions, abnormal
laboratory baseline values, unstable psychiatric features(eg. suicidal), history of
alcohol of drug dependence, seizures, head trauma with loss of consciousness,
neurological illness, or concomitant Axis I psychiatric disorder.
Locations and Contacts
Samsung Medical Center, Kangnam, Seoul 135-710, Korea, Republic of
Additional Information
Starting date: November 2001
Last updated: June 4, 2015
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