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Effect of Preoperative Pregabalin on Propofol Induction Dose

Information source: Universitaire de Sherbrooke
Information obtained from ClinicalTrials.gov on December 08, 2011
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Anesthesia, General; Laparoscopic Surgery

Intervention: Pregabalin (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: Universitaire de Sherbrooke

Official(s) and/or principal investigator(s):
Etienne de Medicis, MD MSc FRCPC, Principal Investigator, Affiliation: Centre Hospitalier Universitaire de Sherbrooke

Overall contact:
Etienne de Medicis, MD MSc FRCPC, Phone: 819-346-1110, Ext: 14953, Email: estria1@globetrotter.net

Summary

The primary issue is to determine whether preoperatively administered pregabalin decreases the necessary dose of propofol during induction of general anesthesia. The investigators secondary issue is to test if preoperatively administered pregabalin decreases anxiety.

Clinical Details

Official title: Effect of Preoperative Pregabalin on Propofol Induction Dose

Study design: Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Propofol induction dose

Secondary outcome: Preoperative anxiety

Eligibility

Minimum age: 18 Years. Maximum age: 40 Years. Gender(s): Female.

Criteria:

Inclusion Criteria:

- Laparoscopic gynaecologic surgery

- Age 18-40 years

- ASA class I or II

- Body mass index 18-30

Exclusion Criteria:

- Allergic to pregabalin or gabapentin

- Chronic renal failure

- Alcohol or drug abuse

- Chronic analgesic use other than acetaminophen or NSAID

- Already taking gabapentin, pregabalin, benzodiazepin or antidepression drug

- Known neurological deficiency

- Suspected difficult intubation or ventilation

- Atypical pseudocholinesterases

Locations and Contacts

Etienne de Medicis, MD MSc FRCPC, Phone: 819-346-1110, Ext: 14953, Email: estria1@globetrotter.net

Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada; Recruiting
Etienne de Medicis, MD MSc FRCPC, Phone: 819-346-1110, Ext: 14953, Email: estria1@globetrotter.net
Etienne de Medicis, MD MSc FRCPC, Principal Investigator
Additional Information

Related publications:

Gajraj NM. Pregabalin: its pharmacology and use in pain management. Anesth Analg. 2007 Dec;105(6):1805-15. Review. Erratum in: Anesth Analg.2008 May;106(5):1584.

Gilron I. Gabapentin and pregabalin for chronic neuropathic and early postsurgical pain: current evidence and future directions. Curr Opin Anaesthesiol. 2007 Oct;20(5):456-72. Review.

Sills GJ. The mechanisms of action of gabapentin and pregabalin. Curr Opin Pharmacol. 2006 Feb;6(1):108-13. Epub 2005 Dec 22. Review.

Kavoussi R. Pregabalin: From molecule to medicine. Eur Neuropsychopharmacol. 2006 Jul;16 Suppl 2:S128-33. Epub 2006 Jun 9. Review.

Hill CM, Balkenohl M, Thomas DW, Walker R, Mathé H, Murray G. Pregabalin in patients with postoperative dental pain. Eur J Pain. 2001;5(2):119-24.

Mathiesen O, Jacobsen LS, Holm HE, Randall S, Adamiec-Malmstroem L, Graungaard BK, Holst PE, Hilsted KL, Dahl JB. Pregabalin and dexamethasone for postoperative pain control: a randomized controlled study in hip arthroplasty. Br J Anaesth. 2008 Oct;101(4):535-41. Epub 2008 Jul 23.

Jokela R, Ahonen J, Tallgren M, Haanpää M, Korttila K. Premedication with pregabalin 75 or 150 mg with ibuprofen to control pain after day-case gynaecological laparoscopic surgery. Br J Anaesth. 2008 Jun;100(6):834-40. Epub 2008 Apr 29.

Jokela R, Ahonen J, Tallgren M, Haanpää M, Korttila K. A randomized controlled trial of perioperative administration of pregabalin for pain after laparoscopic hysterectomy. Pain. 2008 Jan;134(1-2):106-12. Epub 2007 May 15.

Paech MJ, Goy R, Chua S, Scott K, Christmas T, Doherty DA. A randomized, placebo-controlled trial of preoperative oral pregabalin for postoperative pain relief after minor gynecological surgery. Anesth Analg. 2007 Nov;105(5):1449-53, table of contents.

Kong VK, Irwin MG. Gabapentin: a multimodal perioperative drug? Br J Anaesth. 2007 Dec;99(6):775-86. Review.

Memi? D, Turan A, Karamanlio?lu B, Seker S, Türe M. Gabapentin reduces cardiovascular responses to laryngoscopy and tracheal intubation. Eur J Anaesthesiol. 2006 Aug;23(8):686-90.

Fassoulaki A, Melemeni A, Paraskeva A, Petropoulos G. Gabapentin attenuates the pressor response to direct laryngoscopy and tracheal intubation. Br J Anaesth. 2006 Jun;96(6):769-73. Epub 2006 Apr 4.

Menigaux C, Adam F, Guignard B, Sessler DI, Chauvin M. Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery. Anesth Analg. 2005 May;100(5):1394-9, table of contents.

Johansen JW. Update on bispectral index monitoring. Best Pract Res Clin Anaesthesiol. 2006 Mar;20(1):81-99. Review.

Bein B. Entropy. Best Pract Res Clin Anaesthesiol. 2006 Mar;20(1):101-9. Review.

Tiippana EM, Hamunen K, Kontinen VK, Kalso E. Do surgical patients benefit from perioperative gabapentin/pregabalin? A systematic review of efficacy and safety. Anesth Analg. 2007 Jun;104(6):1545-56, table of contents. Review.

Starting date: April 2010
Last updated: March 30, 2011

Page last updated: December 08, 2011

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