The Pathophysiology of Orthostatic Hypotension
Information source: Vanderbilt University
Information obtained from ClinicalTrials.gov on October 04, 2010
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Autonomic Nervous System Diseases; Orthostatic Hypotension
Intervention: Standing or upright tilt (Procedure); Microneurography (Procedure); QSweat (Procedure); Daxor (Radiation); phenylephrine,isoproterenol,nitroprusside,propranolol,edrophonium,atropine,tyramine (Drug); clonidine,yohimbine,metoclopramide,alpha-methyldopa (Drug); BodPod (Procedure); Eye exam (Procedure); Sleep study (Procedure); Pain response testing (Procedure); Metabolic chamber (Procedure); Brain function studies (Procedure)
Phase: N/A
Status: Recruiting
Sponsored by: Vanderbilt University Official(s) and/or principal investigator(s):
David Robertson, MD, Principal Investigator, Affiliation: Vanderbilt University
Emily M Garland, PhD, Study Director, Affiliation: Vanderbilt University
Overall contact:
Bonnie K Black, RN, Phone: 615 343 6862, Email: adc.research@vanderbilt.edu
Summary
The purpose of this study is to determine the cause of low blood pressure in selective
patients who have problems with their involuntary (autonomic) nervous system. These
patients frequently have had symptoms throughout their life, and their disorder might have a
genetic basis. The biochemical, physiological and pharmacological procedures in this study
should help us define the problem and perhaps lead to more effective treatment.
Clinical Details
Official title: The Pathophysiology of Orthostatic Hypotension
Study design: Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Screening
Primary outcome: hemodynamic changes with standing
Secondary outcome: blood and urine hormonesblood volume sympathetic nerve activity quantitative sweat testing Eye function Sleep efficiency Metabolic rate Pain response Responses on questionnaires and computer tasks designed to assess brain function
Eligibility
Minimum age: 12 Years.
Maximum age: 70 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- severe orthostatic hypotension and other autonomic symptoms but do not meet criteria
for standard diagnosis
- non-smokers
- drug-free
- able to give informed consent
- free of pulmonary, renal, hematopoietic, hepatic and cardiac disease
Exclusion Criteria:
- medications affecting the autonomic nervous system
- any chronic illness
- anemia (Hct<30)
- women of childbearing age who are pregnant or nursing
- smokers
Locations and Contacts
Bonnie K Black, RN, Phone: 615 343 6862, Email: adc.research@vanderbilt.edu
Vanderbilt University, Nashville, Tennessee 37232, United States; Recruiting
Black, Phone: 615-343-6862
Additional Information
Autonomic Dysfunction Center Website
Starting date: December 1996
Last updated: January 11, 2010
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