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The Pathophysiology of Orthostatic Hypotension

Information source: Vanderbilt University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Autonomic Nervous System Diseases; Orthostatic Hypotension; Dopamine Beta-Hydroxylase Deficiency; Orthostatic Intolerance

Intervention: Standing or upright tilt (Procedure); Microneurography (Procedure); QSweat (Procedure); neck cuff stimulation (Device); phenylephrine,isoproterenol,nitroprusside,propranolol,edrophonium,atropine,tyramine (Drug); clonidine,yohimbine,metoclopramide,alpha-methyldopa (Drug); BodPod (Procedure); Eye exam (Procedure); Sleep study (Procedure); Pain response testing (Procedure); Metabolic chamber (Procedure); Brain function studies (Procedure); Bicycle Exercise Test (Procedure)

Phase: N/A

Status: Active, not recruiting

Sponsored by: Vanderbilt University

Official(s) and/or principal investigator(s):
David Robertson, MD, Principal Investigator, Affiliation: Vanderbilt University
Emily M Garland, PhD, Study Director, Affiliation: Vanderbilt University

Summary

The purpose of this study is to determine the cause of low blood pressure in selective patients who have problems with their involuntary (autonomic) nervous system. These patients frequently have had symptoms throughout their life, and their disorder might have a genetic basis. The biochemical, physiological and pharmacological procedures in this study should help us define the problem and perhaps lead to more effective treatment.

Clinical Details

Official title: The Pathophysiology of Orthostatic Hypotension

Study design: Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Screening

Primary outcome: hemodynamic changes with standing

Secondary outcome:

blood and urine hormones

blood volume

sympathetic nerve activity

quantitative sweat testing

Eye function

Sleep efficiency

Metabolic rate

Pain response

Responses on questionnaires and computer tasks designed to assess brain function

Eligibility

Minimum age: 12 Years. Maximum age: 70 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- severe orthostatic hypotension and other autonomic symptoms but do not meet criteria

for standard diagnosis

- non-smokers

- drug-free

- able to give informed consent

- free of pulmonary, renal, hematopoietic, hepatic and cardiac disease

Exclusion Criteria:

- medications affecting the autonomic nervous system

- any chronic illness

- anemia (Hct<30)

- women of childbearing age who are pregnant or nursing

- smokers

Locations and Contacts

Vanderbilt University, Nashville, Tennessee 37232, United States
Additional Information

Autonomic Dysfunction Center Website

Starting date: December 1996
Last updated: June 15, 2015

Page last updated: August 23, 2015

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