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Efficacy and Tolerability of Flunarizine for the Treatment of Schizophrenia: Comparison With Haloperidol

Information source: Ambulatório de Bipolaridade
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Schizophrenia

Intervention: Flunarizine (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Ambulatório de Bipolaridade

Summary

Flunarizine is a calcium channel blocker traditionally used for the treatment of vertigo and migraine. It also has the mechanism of action associated with antipsychotic activity (D2 receptor blockade), but has never been tested as such. The investigators hypothesis is that flunarizine can be an atypical antipsychotic.

Clinical Details

Official title: Is Flunarizine a Cheap, Well-Tolerated and Long-Acting Atypical Antipsychotic? A Randomized Double-Blind Flexible-Dose Clinical Trial Versus Haloperidol for the Treatment of Schizophrenia

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Detailed description: The main advantage of flunarizine over other D2 receptor blockers is its long half-life, so that it may be administered weekly or may delay relapse if medication is interrupted.

Eligibility

Minimum age: 18 Years. Maximum age: 60 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- DSM-IV schizophrenic or schizoaffective patients between 18 and 55 years old with a

PANSS score above 45. Exclusion Criteria:

- Clinical disease

- Pregnancy

- Drug dependence (except for nicotine) in the past month and history of being

refractory to at least 2 antipsychotics taken appropriately.

Locations and Contacts

Universidade Federal de São Paulo, São Paulo, SP 04023-900, Brazil
Additional Information

Starting date: September 2004
Last updated: August 20, 2008

Page last updated: August 23, 2015

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