A Phase III Superiority Study of Vernakalant vs Amiodarone in Subjects With Recent Onset Atrial Fibrillation

Condition(s) targeted: Atrial Fibrillation

Intervention: Vernakalant Injection (Drug); Amiodarone Injection: (Drug)

Phase: Phase 3

Status: Recruiting

Sponsored by: Cardiome Pharma

Official(s) and/or principal investigator(s):
Tomas Janota, MD, Principal Investigator, Affiliation: VFN III. interní klinika
Christian Torp-Pedersen, MD, Principal Investigator, Affiliation: Gentofte Amtssygehus - Kardiologisk afdeling
Rein Kolk, MD, Principal Investigator, Affiliation: Tartu University Hospital Heart Clinic
Etienne Aliot, MD, Principal Investigator, Affiliation: CHU de Nancy - Hopital Brabois, Service de Cardiologie
Stefan Hohnloser, MD, Principal Investigator, Affiliation: Johann Wolfgang Goethe Universitaet Med Klinik III - Kardiologie
Heikki Huikuri, MD, Principal Investigator, Affiliation: Oulu University Hospital - Dept of Internal Medicine
Piotr Ponikowski, MD, Principal Investigator, Affiliation: Osrodek Chorob Serca, Klinika Kardiologii, IV Wojskowy Szpital Kliniczny z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej we Wroclawiu
Steen Juul-Moller, MD, Principal Investigator, Affiliation: Universitetssjukhuset MAS

Overall contact:
Heather Kato, MAppSc, Phone: 604-677-6905, Ext: 135, Email: hkato@cardiome.com

The primary objective of the study is to demonstrate the superiority of vernakalant injection over amiodarone injection in the conversion of atrial fibrillation (AF) to sinus rhythm (SR) within 90 minutes of the start of drug administration. The secondary objective is to compare the safety of vernakalant to amiodarone.

Official title: A Phase III Prospective, Randomized, Double-Blind, Active-Controlled, Multi-Center, Superiority Study of Vernakalant Injection Versus Amiodarone in Subjects With Recent Onset Atrial Fibrillation

Study design: Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Active Control, Parallel Assignment, Safety/Efficacy Study

Primary outcome: Proportion of subjects with conversion of atrial fibrillation to sinus rhythm within 90 minutes after the start of infusion.

Secondary outcome:

Time to conversion within 90 minutes after the start of infusion.

Proportion of subjects with symptom relief at 90 minutes after the start of infusion.

EQ-5D quality of life assessment.

Monitoring of adverse events, vital signs, continuous telemetry monitoring, 12-lead Holter monitoring, 12-lead ECGs, and laboratory tests.

Detailed description: This is a double-blind, active-controlled, double-dummy, multi-center, randomized trial in subjects with symptomatic AF of 3 to 48 hours duration.

Subjects will be randomized to receive vernakalant injection or amiodarone injection in a 1: 1 ratio.

Safety will be assessed through the monitoring of adverse events, vital signs, continuous telemetry monitoring, 12-lead Holter monitoring, 12-lead ECGs, and laboratory tests.

At 2 hours after the start of infusion, electrical cardioversion may be performed or rate control medication may be administered. Class I and Class III antiarrhythmics are not to be administered for 24 hours after the start of infusion.

Subjects are to remain in the clinic for at least 6 hours after the start of infusion. Subjects will attend a follow-up visit at 7 (±2) days after treatment and will receive a follow-up telephone call at 30 (±3) days for assessment of serious adverse events, concomitant medications related to serious adverse events, and recurrence of AF.

All roles were blinded with the exception of each site's designated unblinded personnel who were responsible for randomization and preparation, dispensation and accountability of the study medication.

Expanded Access was not available through this protocol.

Minimum age: 18 Years. Maximum age: 85 Years. Gender(s): Both.

Criteria:

Key Inclusion Criteria:

- Have symptomatic AF of 3 to 48 hours duration at baseline.

- Be eligible for cardioversion.

- Have adequate anticoagulation therapy for cardioversion in accordance with standard

of practice as recommended by ACC/AHA/ESC guidelines [1].

- Be hemodynamically stable and have systolic blood pressure (BP) above 100 mmHg and

less than 160 mmHg and diastolic BP less than 95 mmHg at screening and baseline.

Key Exclusion Criteria:

- Known or suspected prolonged QT or uncorrected QT interval of >440 msec as measured

at screening on a 12 lead ECG, familial long QT syndrome, or previous torsades de pointes, ventricular fibrillation; or sustained ventricular tachycardia (VT).

- Symptomatic bradycardia, sick sinus syndrome, or ventricular rate less than 50 beats

per minute (bpm) as documented by 12-lead ECG at screening.

- A QRS interval >140 msec.

- Atrial flutter.

- Significant valvular stenosis, hypertrophic obstructive cardiomyopathy, restrictive

cardiomyopathy or constrictive pericarditis.

- Documented previous episodes of second or third degree atrioventricular (AV) block.

- Had a myocardial infarction (MI), acute coronary syndrome or cardiac surgery within

30 days prior to entry into the study.

- Uncorrected electrolyte imbalance of serum potassium or magnesium. Both K+ and Mg2+

must be corrected prior to dosing.

Heather Kato, MAppSc, Phone: 604-677-6905, Ext: 135, Email: hkato@cardiome.com

Mestrska nemocnice Caslav, Caslav 286 01, Czech Republic; Recruiting
Hana Grunfeldova, MD, Phone: 420 327 305 152, Email: grunfeldova@email.cz
Hana Grunfeldova, MD, Principal Investigator

Nemocnice Kroměříž, Kroměříž 767 55, Czech Republic; Terminated

Nemocnice Kutna Hora s.r.o. Interni Oddeleni, Kutna Hora, Czech Republic; Terminated

Nemocnice Decin Internal Medicine, Nove Město 405 02, Czech Republic; Recruiting
Michal Hondl, MD, Phone: 420 737 889 772, Email: michal.hondl@nemdc.cz
Michal Hondl, MD, Principal Investigator

VFN - III. Interni Klinika, Praha, Czech Republic; Recruiting
Tomas Janota, MD, Phone: 420-224-962-934
Tomas Janota, MD, Principal Investigator

Ustredni vojenska nemocnice Koronarni jednotka, Praha 162 00, Czech Republic; Terminated

Fakultní nemocnice v Motole, KAR, Praha 150 00, Czech Republic; Terminated

Oblastni nemocnice Pribram Interni Oddeleni, Pribram, Czech Republic; Terminated

Nemocnice v Semilech Interní oddělení, Semily, Czech Republic; Recruiting
Pavel Sabl, MD, Phone: 420-481-661-333
Pavel Sabl, MD, Principal Investigator

Nemocnice Slaný Interní oddělení, Slaný, Czech Republic; Recruiting
Ondrej Cermak, MD, Phone: 420-312-575-338
Ondrej Cermak, MD, Principal Investigator

Nemocnice Tabor, Tabor 390 03, Czech Republic; Recruiting
Jana Mikulova, MD, Phone: 420 602 692 259, Email: janamikulova@seznam.cz
Jana Mikulova, MD, Principal Investigator

Uherskohradistska nemocnice, Uherské Hradiste 686 08, Czech Republic; Recruiting
Stanislav Zemek, MD, Phone: 420 724 631 007, Email: zemeks@post.cz
Stanislav Zemek, MD, Principal Investigator

Gentofte Amtssygehus Kardiologisk afdeling, Hellerup, Denmark; Recruiting
Gitte von Jessen, Phone: 45 35 31 27 71, Email: gvj@heart.dk
Christian Torp-Pedersen, MD, Principal Investigator

Herlev Amtssygehus, Kardiologisk, Herlev 2730, Denmark; Terminated

Sygehus Vendsyssel Hjorring, Hjorring, Denmark; Recruiting
Jens Petersen, MD, Phone: 45 99 64 31 01
Jens Petersen, MD, Principal Investigator

Roskilde Amts Sygehus Køge, Koge, Denmark; Recruiting
Lone Brinksby, Phone: 45 47 32 25 56
Kim Klarlund, MD, Principal Investigator

Regionshospitalet Silkeborg, Silkeborg, Denmark; Recruiting
Malene Mortensen, Phone: 45 87 22 23 49, Email: projektM1@sc.aaa.dk
Lars Frost, MD, Principal Investigator

Viimsi Hospital, Heart Clinic, Haabneeme 74001, Estonia; Recruiting
Juri Kaik, MD, Phone: 372 5 031931, Email: Jyri.Kaik@mail.ee
Juri Kaik, MD, Principal Investigator

Pärnu Hospital Department of Cardiology, Parnu, Estonia; Recruiting
Veiko Vahula, MD, Phone: 372 44 73310
Veiko Vahula, MD, Principal Investigator

East Tallinn Central Hospital-Clinic of Cardiology, Tallinn, Estonia; Recruiting
Anne Kork, MD, Phone: 372 62 07056
Anne Kork, MD, Principal Investigator

Tartu University Hospital Heart Clinic, Tartu, Estonia; Active, not recruiting

Oulu University Hospital - Dept of Internal Medicine, Oulu 90014, Finland; Active, not recruiting

Hopital Trousseau - Service de Cardiologie, Chambray-les-Tours, France; Recruiting
Dominique Babuty, MD, Phone: 33 0 247 47 46 50
Dominique Babuty, MD, Principal Investigator

CHU de Nancy - Hopital Brabois - Service de Cardiologie, Nancy, France; Recruiting
Etienne Aliot, MD, Phone: 33 3 83 15 32 96
Etienne Aliot, MD, Principal Investigator

Hôpital Lariboisiere, Paris, France; Terminated

CHU de Strasbourg - Hopital Hautepierre - Service de Cardiologie, Strasbourg, France; Terminated

Campus Virchow-Klinikum, Charite - Universitaetsmedizin Berlin, Berlin, Germany; Recruiting
Wilhelm Haverkamp, MD, Phone: 49 30 450 653366
Wilhelm Haverkamp, MD, Principal Investigator

Charite Campus Mitte, Med. Klinik und Poliklinik mit Schwerpunkt Kardiologie und Angiologie, Berlin 10117, Germany; Terminated

Herzzentrum Brandenburg in Bernau Innere Medizin, Bernau 16321, Germany; Recruiting
Christian Butter, MD, Phone: 49 3 338 694 610, Email: c.butter@immanuel.de
Christian Butter, MD, Principal Investigator

Universitätsklinikum Bonn, Med. Klinik und Poliklinik II, Bonn 53105, Germany; Terminated

Johann Wolfgang Goethe Universitaet Med Klinik III - Kardiologie, Frankfurt, Germany; Recruiting
Stefan Hohnloser, MD, Phone: 49 69 6301 7404
Stefan Hohnloser, MD, Principal Investigator

Universitatsklinikum Gottingen, Herzzentrum, Gottingen 37075, Germany; Recruiting
Rolf Wachter, MD, Phone: 49 551 398920
Rolf Wachter, MD, Principal Investigator

Martin-Luther Universitat Halle, Med. Klinik und Poliklinik III- Fachrichtung Kardiologie, Halle, Germany; Recruiting
Michael Buerke, MD, Phone: 49 221 4783 2401
Michael Buerke, MD, Principal Investigator

Klinik Hamburg Bambek Kardiologie, Hamburg 22291, Germany; Recruiting
Thora Botschafter, Phone: 49 40 18 18 82 6317, Email: t.botschafter@asklepios.com
Gerian Grönefeld, MD, Principal Investigator

Medizinisches Versorgungszentrum Prof. Mathey, Prof. Schofer GmbH, Hamburg 22527, Germany; Recruiting
Dr. Tuebler, MD, Phone: 49 40 889 009 899
Frau Hoffmann, Phone: 49 40 889 009 899, Email: hoffmann@herz-hh.de
Carsten Schwencke, MD, Principal Investigator

Medizinische Klinik, Klinikum Hannover Nordstadt, Hannover, Germany; Recruiting
Johannes Hensen, MD, Phone: 49 511 9701291
Johannes Hensen, MD, Principal Investigator

Ambulantes Herzzentrum Kassel Innere Medizin, Kassel 34121, Germany; Recruiting
Ines Pietsch, Phone: 49 (0)561 93769150
Petra Becker, Phone: 49 (0)561 93769150
Andreas Utech, MD, Principal Investigator

Klinikum der Universität Köln, Medizinische Klinik III, Köln 50924, Germany; Terminated

Klinikum der Stadt Ludwigshafen am Rhein gGmbH, Ludwigshafen 67063, Germany; Recruiting
Petra Zaricor, Phone: 49 621 503 4354, Email: zaricorp@klilu.de
Karlheinz Seidl, MD, Principal Investigator

Carl-von Basedow-Klinikum Merseburg, Merseburg 06217, Germany; Recruiting
Frau Dr. Susanne Rode, MD, Email: S.Burghard@klinikum-saalekreis.de
Roland Prondzinsky, MD, Principal Investigator

Klinikum Pirna GmbH, Innere Medizin II, Kardiologie, Pirna, Germany; Recruiting
Christoph Axthelm, MD, Phone: 49 3501 7118 5041
Christoph Axthelm, MD, Principal Investigator

Krankenhaus Reinbek, St. Adolf-Stift, Reinbek, Germany; Recruiting
Herbert Naegele, MD, Phone: 49 40 72805158
Herbert Naegele, MD, Principal Investigator

Robert-Bosch-Krankenhaus, Abt. Kardiologie / Pulmologie, Stuttgart 70376, Germany; Terminated

Latvian Center of Cardiology, P. Stradins Clinical University Hospital, Riga LV1002, Latvia; Recruiting
Iveta Mintale, Phone: 371 67069959, Email: iveta.mintale@stradini.lv
Andrejs Erglis, MD, Principal Investigator

Kaunas Medical University Hospital - Department of Cardiology, Kaunas, Lithuania; Active, not recruiting

Klaipeda Seamen's Hospital, Klaipeda, Lithuania; Active, not recruiting

Vilnius University Hospital Santariskiu Clinic - Center of Cardiology and Angiology, Vilnius, Lithuania; Active, not recruiting

WCN - Department of Cardiology Rijnstate Ziekenhuls, Arnhem 6-800 TA, Netherlands; Recruiting
F F Willems, MD, Phone: 31 88 005 7543, Email: f.willem7@chello.nl
F F Willems, MD, Principal Investigator

Catharina Ziekenhuis Eindhoven, Eindhoven 5623EJ, Netherlands; Recruiting
Antoinette Spierings, Phone: 31 40 2398362, Email: carapl@cze.nl
H R Michels, MD, Principal Investigator

Groene Hart Zeikenhhaus, Gouda 2800BB, Netherlands; Recruiting
Marijke de Wit, Phone: 31 18 250 5360, Email: marijke.de.wit@ghz.nl
Mrs. Kramer, Phone: 31 18 250 5360, Email: hanneke.kramer@ghz.nl
Eric Viergever, MD, Principal Investigator

WCN - Bethesda ziekenhuis, Hoogeveen 7909 AA, Netherlands; Recruiting
S H K The, MD, Phone: 31 052 828 6222, Email: shkthe@bethesda.nl
S H K The, MD, Principal Investigator

Academisch Ziekenhuis Maastricht, Maastricht 6229 HX, Netherlands; Recruiting
Iris Partouns-Hendricks, Phone: 31 43 387 7091, Email: iris.partouns.hendricks@mumc.nl
An Moens, MD, Principal Investigator

WCN - Canisius-Wilhelmina Ziekenhuis, Nijmegen 6532 SZ, Netherlands; Recruiting
Astrid Schut, Phone: 31 24 365 8789, Email: Res.car@cwz.nl
D P Hertzberger, MD, Principal Investigator

WCN - St. Franciscus Gasthuis, Rotterdam 3045 PM, Netherlands; Recruiting
Irene Kort, Phone: 31 10 461 6790, Email: i.kort@sfg.nl
Ingrid Danse, Phone: 31 10 461 6790, Email: i.danse@sfg.nl
P R Nierop, MD, Principal Investigator

Oddzial Kardiologiczny Wielospecjalityczny Szpital Miejski im., Bydgoszcz, Poland; Recruiting
Andrzej Hoffmann, MD, Phone: 48 52 3709300
Andrzej Hoffmann, MD, Principal Investigator

Szpital Miejski im. J. Brudzinskiego Oddzial Kardiologii, Gdynia, Poland; Recruiting
Pawel Miekus, MD, Phone: 48 58 6665580
Pawel Miekus, MD, Principal Investigator

Klinika Chorob Wewnetrznych z Oddzialem Farmakologii Klinicznej i Terapii Monitorowanej, Lodz, Poland; Recruiting
Marlena Broncel, MD, Phone: 48 42 2516002
Marlena Broncel, MD, Principal Investigator

Okregowy Szpital Kolejowy w Lublinie Samodzielny, Lublin, Poland; Active, not recruiting

Oddział Internistyczno-Kardiologiczny Samodzielny Publiczny Szpital Wojewódzki im. Jana Bożego w Lublinie, Lublin 20-089, Poland; Recruiting
Hanna Lewandowska, MD, Phone: 48 81 740 26 75, Email: hannals@o2.pl
Hanna Lewandowska, MD, Principal Investigator

Oddzial Kardiologii Inwazyjnej Szpital Specjalistyczny im. E.Szczeklika w Tarnowie, Tarnow 33-100, Poland; Terminated

Oddział Kardiologiczno-Internistyczny Specjalistyczny Szpital Miejski im. Mikołaja Kopernika, Toruń 87-100, Poland; Recruiting
Bartłomiej Jończy, MD, Phone: 48 56 610 02 50, Email: bartjon@o2.pl
Bartłomiej Jończy, MD, Principal Investigator

Specjalistyczny Szpital Miejski im. Mikołaja Kopernika, Toruń 87-100, Poland; Recruiting
Lidia Pawlowicz, MD, Phone: 48 56 610 02 45, Email: lpawlowicz@ksiaznica.torun.pl
Lidia Pawlowicz, MD, Principal Investigator

Wojskowy Instytut Medyczny, CSK MON, Warszawa 00-909, Poland; Recruiting
Leszek Kubik, MD, Phone: 48 22 6816585
Leszek Kubik, MD, Principal Investigator

III Klinika Chorob Wewnetrznych i Kardiologii, Warszawa 00-382, Poland; Recruiting
Krzysztof Makowiecki, MD, Phone: 48 22 6252231
Krzysztof Makowiecki, MD, Principal Investigator

Klinika Kardiologii Zachowawczej Centralny Szpital Kliniczny Ministerstwa Spraw Wewnętrznych i Administracji w Warszawie, Warszawa 02-507, Poland; Recruiting
Marek Kochmański, Phone: 48 22 508 16 70
Marek Kochmański, MD, Principal Investigator

Osrodek Chorob Serca, Klinika Kardiologii, 4 Wojskowy Szpital Kliniczny z Poliklinika Samodzielny, Wroclaw, Poland; Recruiting
Piotr Ponikowski, MD, Phone: 48 71 7660250
Piotr Ponikowski, MD, Principal Investigator

"Dedinje" Cardiovascular Institute, Belgrade 11040, Serbia; Recruiting
Petar Otasevic, Phone: 381 11 360 16 69, Email: potasevic@yahoo.com
Milorad Borzanovic, MD, Principal Investigator

Clinical Center of Serbia, Institute of CV Diseases, Belgrade 11000, Serbia; Recruiting
Arsen Ristic, Phone: 381 11 361 47 38
Petar Seferovic, MD, Principal Investigator

Institute of Treatment and Reahabilitation 'Niska Banja', Niska Banja 18205, Serbia; Recruiting
Bojan Ilic, Phone: 381 18 450 22 26, Email: bojanil@eunet.rs
Stevan Ilic, MD, Principal Investigator

Clinical Center Zemun, Dept. of Cardiology, Zemun 11080, Serbia; Recruiting
Predrag Milicevic, Phone: +381 11 377 27 62, Email: milicevicp@hotmail.com
Putnikovic Biljana, MD, Principal Investigator

Middle Slovak Institute of Cardiovascular Diseases (SUSCCH), Banska Bysterica 97401, Slovakia; Recruiting
Gabriela Kaliska, MD, Phone: 421 48 441 3059
Gabriela Kaliska, MD, Principal Investigator

NsP Prievidza so sidlom v Bojniciah, Bojnice 97201, Slovakia; Terminated

Slovensky ustav srdcovych a cevnych chorob, Bratislava 83348, Slovakia; Terminated

ICU, Hospital Lipt. Mikulas, Liptovsky Mikulas 03101, Slovakia; Recruiting
Peter - Kycina, MD
Peter - Kycina, MD, Principal Investigator

FN - I. interna klinika, Nitra 950 01, Slovakia; Terminated

Liva - Central Military Hospital, Ruzomberok 03401, Slovakia; Recruiting
Miroslav Urban, MD, Phone: 421 44 438 2844
Miroslav Urban, MD, Principal Investigator

Interna klinika FN Trnava, Fakultna nemocnica Trnava, Trnava 91701, Slovakia; Recruiting
Vladimir Macek, MD, Phone: 421 33 593 8251
Vladimir Macek, MD, Principal Investigator

Internal Dep. Hospital Žilina, Žilina 012 07, Slovakia; Terminated

Universitetssjukhuset MAS, Malmo, Sweden; Active, not recruiting

Universityetssjukhuset, Orebro, Orebro, Sweden; Recruiting
Lena Swedberg, Phone: 46 19 602 1000
Espen Fensgrud, MD, Principal Investigator

Akademiska Sjukhuset, Uppsala, Uppsala, Sweden; Recruiting
Yvonne Björkman, Phone: 46 18 6112738
Per Blomstrom, MD, Principal Investigator

Donetsk Regional Clinical Hospital, Donetsk, Ukraine; Terminated

City Clinical Hospital #8, Kharkiv, Ukraine; Terminated

Kiev City Clinical Hospital No 5, Coronary Care Unit, Kiev, Ukraine; Terminated

City Clinical Hospital #1 Intensive Care Unit, Kiev, Ukraine; Terminated

N.D. Strazhesko Institute of Cardiology Intensive Care Unit, Kiev, Ukraine; Terminated

Lugansk First Clinical Multiprofile Hospital #1, Cardiology, Lugansk, Ukraine; Terminated

Lviv Reg St Clinical Treat-and-Diagn Cardio. Centre Dept of Myocardial Infarction, Lviv, Ukraine; Terminated

City Clinical Hospital #9 Dept of Arrhythmia, Odessa, Ukraine; Terminated

Kingston General Hospital, Kingston, Ontario K7L 2V7, Canada; Recruiting
Kathryn Bowes, Phone: 613 549 6666, Ext: 2738, Email: Bowesk@kgh.kari.net
Marco Sivilotti, MD, Principal Investigator

The Ottawa Hospital, Ottawa, Ontario K1Y 4E9, Canada; Recruiting
Cathy Clement, RN, Phone: 613 798 5555, Ext: 16615, Email: cclement@ohri.ca
Ian Stiell, MD, Principal Investigator

Hopital de la Cite-de-la-Sante, Laval, Quebec H7M 3L9, Canada; Recruiting
Eric Daviau, Phone: 450-668-1010, Ext: 2132, Email: recherché.cardiologie.csssl@ssss.gouv.qc.ca
Mayrand Helene, MD, Principal Investigator

Institut de Cardiologie de Montreal, Montreal, Quebec H1T 1C8, Canada; Recruiting
Constance Bossy, RN, Phone: 514 376 3330, Ext: 2884, Email: Constance.Bossy@icm-mhi.org
Denis Roy, MD, Principal Investigator

Centre Hopitalier de L'Universite de Montreal - Hotel Dieu, Montreal, Quebec H2W 1T8, Canada; Recruiting
Carole Lemay, RN, Phone: 514 890 8000, Ext: 14803, Email: recherche.cardio.hd.chum@ssss.gouv.gc.ca
Paolo Costi, MD, Principal Investigator

McGill University Health Center The Montreal General Hospital, Montreal, Quebec H3G 1A4, Canada; Recruiting
Caroline Boudreault, Phone: 514 934 1934, Ext: 43038, Email: caroline.boudreault@muhc.mcgill.ca
Thao Huynh, MD, Principal Investigator

Centre de santé et de services sociaux du Sud de Lanaudière - Hôpital Pierre-Le Gardeur, Terrebonne, Quebec J6V 2H2, Canada; Recruiting
Margaux David, RN, Phone: 450 654 7525, Ext: 11104, Email: chlg.rech.cardio@ssss.gouv.qc.ca
Denis-Carl Phaneuf, MD, Principal Investigator

Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia; Recruiting
Ashley Roach, Phone: 61 08 82222889, Email: ashley.roach@health.sa.gov.au
Julie Bradley, MD, Principal Investigator

Royal Hobart Hospital Cardiology Research, Hobart, Tasmania 7000, Australia; Recruiting
Cathy McIntosh, Phone: 61 3 6222 8287, Email: cathy.mcintosh@dhhs.tas.gov.au
Phil Roberts-Thomson, MD, Principal Investigator

Launceston General Hospital Cardiac Research Unit, Launceston, Tasmania, Australia; Recruiting
Gail McBain, Phone: 61 3 63487583, Email: gail.mcbain@dhhs.tas.gov.au
Bhuwan Singh, MD, Principal Investigator

Royal Perth Hospital Emergency Research, Perth, Western Australia 6000, Australia; Recruiting
Ellen MacDonald, Phone: 61 8 9224 1724, Email: ellen.macdonald@heath.wa.gov.au
Simon Brown, MD, Principal Investigator

Starting date: April 2008
Ending date: October 2009
Last updated: October 13, 2009