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The Role of COX-2 Inhibition in Salt Sensitivity of Blood Pressure

Information source: University of Delaware
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Hypertension

Intervention: celecoxib (Celebrex) (Drug); Placebo (Other)

Phase: Phase 4

Status: Completed

Sponsored by: University of Delaware

Official(s) and/or principal investigator(s):
William B Farquhar, PhD, Principal Investigator, Affiliation: University of Delaware
Michael Stillabower, MD, Study Director, Affiliation: Christiana Care Health Services

Summary

The purpose of this study is to determine if the drug Celebrex changes the way the kidney gets rid of salt and maintains blood pressure.

Clinical Details

Official title: COX-2 Regulation of Renal Sodium Handling in Blood Pressure Maintenance

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science

Primary outcome: Mean Arterial Pressure

Secondary outcome: Urinary Sodium Excretion

Detailed description: There have been many studies done with analgesics such as acetaminophen and non-steroidal anti-inflammatory drugs; however it is not understood how blood pressure changes while using Celebrex. The study hypothesis is that Celebrex will increase salt sensitivity of blood pressure.

Eligibility

Minimum age: 22 Years. Maximum age: 50 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- healthy men and women

Exclusion Criteria:

- history of heart disease

- have had heart surgery

- high blood pressure

- diabetes

- cancer

- any other disease such as kidney or neurological diseases

- taking medications such as aspirin or medicines for your heart or blood pressure

- have asthma or are allergic to sulfa drugs

- body mass index greater than 30

- use tobacco

- pregnant

- women using oral contraceptives or hormone replacement therapy

Locations and Contacts

University of Delaware, Newark, Delaware 19716, United States
Additional Information

Starting date: February 2008
Last updated: January 4, 2012

Page last updated: August 20, 2015

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