Ketamine Compared to Propofol for Pediatric GI Endoscopy
Information source: State University of New York - Upstate Medical University
Information obtained from ClinicalTrials.gov on November 03, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Endoscopy
Intervention: Ketamine (Drug); Propofol (Drug)
Phase: N/A
Status: Recruiting
Sponsored by: State University of New York - Upstate Medical University Overall contact:
Kimberly A Kasprowicz, MS,RN,FNP, Phone: 315-464-4892, Email: kasprowk@upstate.edu
Summary
Elective outpatient endoscopy for children can be safely performed under general anesthesia
with either propofol (1) or ketamine (2) infusions. Both infusions have an advantage over
general anesthesia with volatile agents because they do not require intubation. The goal of
both infusions is to have the patient breath spontaneously without reacting to the endoscopy
which is a noxious stimulus. Patient movement, stridor and vomiting are can interrupt the
procedure and increase overall OR time. Propofol also carries the added risk of causing
apnea. This side effect is not commonly seen with Ketamine. Our hypothesis is that
Ketamine's profile makes it a superior drug to Propofol for elective outpatient endoscopy
because of reduced profound intra-operative interruptions and faster recovery time. We plan
a study of pediatric patients ages 1 to 10 years old undergoing elective outpatient
endoscopy. The patients will be randomized to receiving either a Ketamine or Propofol
infusion, and the intra-operative interruptions will be documented by the anesthesiologist.
The Post Anesthetic Care Unit (PACU) time to recovery will be monitored and recorded by a
third party.
Clinical Details
Study design: Cohort, Prospective
Eligibility
Minimum age: 1 Year.
Maximum age: 10 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Age 1-10
- Endoscopy with sedation scheduled
Exclusion Criteria:
- A history of chronic respiratory disease
- Upper respiratory infection
- Developmental delays
- Dysrhythmias
- Increased intercranial pressure
- Any sedatives or narcotics up to 6 weeks prior to procedure.
Locations and Contacts
Kimberly A Kasprowicz, MS,RN,FNP, Phone: 315-464-4892, Email: kasprowk@upstate.edu
Upstate Medical University, Syracuse, New York 13210, United States; Recruiting
Kimberly A Kasprowicz, MS, RN, FNP, Phone: 315-464-4892, Email: kasprowk@upstate.edu
Additional Information
Starting date: October 2007
Ending date: October 2008
Last updated: February 12, 2008
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