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Losartan and HCTZ and Amlodipine vs Atenolol and Amlodipine (0954A-309)(COMPLETED)

Information source: Merck Sharp & Dohme Corp.
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Hypertension

Intervention: MK0954, losartan potassium/Duration of Treatment: 18 weeks (Drug); Comparator: losartan, HCTZ, amlodipine, atenolol/Duration of Treatment: 18 weeks (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Merck Sharp & Dohme Corp.

Official(s) and/or principal investigator(s):
Medical Monitor, Study Director, Affiliation: Merck Sharp & Dohme Corp.

Summary

A study to evaluate the effects of combination losartan versus combination atenolol in patients with ambulatory systolic hypertension.

Clinical Details

Official title: Antihypertensive Effects of a Fixed-dose Combination of Losartan and Hydrochlorothiazide Plus Amlodipine Versus a Hydrochlorothiazide and Atenolol Combination Plus Amlodipine in Subjects With Ambulatory Systolic Hypertension.

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Mean daytime ambulatory systolic blood pressure

Secondary outcome:

Ambulatory BP

Pulse pressure

Trough sitting BP

Percentage of patients who reach goal ambulatory systolic BP

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Males or females at least 18 years of age who have ambulatory systolic hypertension.

Locations and Contacts

Additional Information

Related publications:

Lacourcière Y, Poirier L, Lefebvre J. Expedited blood pressure control with initial angiotensin II antagonist/diuretic therapy compared with stepped-care therapy in patients with ambulatory systolic hypertension. Can J Cardiol. 2007 Apr;23(5):377-82.

Starting date: February 2003
Last updated: March 27, 2015

Page last updated: August 23, 2015

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