Assessment of Potential Interactions Between Cocaine and Tolcapone - 1
Information source: National Institute on Drug Abuse (NIDA)
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Cocaine-Related Disorders
Intervention: Tolcapone (Drug)
Phase: Phase 1
Status: Active, not recruiting
Sponsored by: National Institute on Drug Abuse (NIDA) Official(s) and/or principal investigator(s):
Thomas Newton, M.D., Principal Investigator, Affiliation: National Institute on Drug Abuse (NIDA)
Summary
The purpose of this study is to assess the potential interactions between intravenous (IV)
cocaine and tolcapone.
Clinical Details
Official title: Assessment of Potential Interactions Between Intravenous Cocaine and Tolcapone
Study design: Treatment, Randomized, Double-Blind, Placebo Control
Primary outcome: Safety
Detailed description:
Double-blind, inpatient study by screening responses to cocaine infusions of 20 and 40 mg
i. v. subjects into 1 of 2 treatment groups to assess potential interactions between i. v.
cocaine infusion and treatment with tolcapone.
Eligibility
Minimum age: 18 Years.
Maximum age: 45 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
Volunteers dependent on cocaine and are non-treatment seeking; between 18-45 yrs of age;
DSM-4 criteria for cocaine abuse or dependence
Exclusion Criteria:
Additional criteria available during screening at the site
Locations and Contacts
UCLA Integrated Substance Abuse Program, Los Angeles, California 90024, United States
Additional Information
Starting date: July 2001
Ending date: March 2002
Last updated: February 8, 2007
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