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Individual Differences in the Response to Drugs

Information source: University of Chicago
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Healthy

Intervention: Oral THC (Drug); d-Amphetamine (Drug); Alcohol (Drug); Placebo capsules (Other); Placebo drink (Other)

Phase: N/A

Status: Completed

Sponsored by: University of Chicago

Official(s) and/or principal investigator(s):
Harriet de Wit, PhD, Principal Investigator, Affiliation: University of Chicago

Summary

The purpose of this study is to examine whether individual differences in acute responses to drugs co-vary across three drugs from different drug classes: alcohol, amphetamine and delta-9-tetrahydrocannabinol (THC). The investigators hypothesize that individuals who experience greater rewarding effects from one drug will also experience more rewarding effects from the other drugs.

Clinical Details

Official title: A Preliminary Investigation of Individual Differences in Subjective Responses to D-amphetamine, Alcohol, and Delta-9-tetrahydrocannabinol

Study design: Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science

Primary outcome:

Subjective Measures: Change in General Drug Effects (Drug Effects Questionnaire) Over Time

Subjective Measures: Change in Specific Drug Effects (Addiction Research Center Inventory) Over Time

Subjective Measures: Change in Mood (Profile of Mood States) Over Time

Secondary outcome:

Physiological Measures: Change in Heart Rate (Beats per Minute) Over Time

Physiological Measures: Change in Blood Pressure (mm Hg) Over Time

Detailed description: Here, the investigators aim to investigate whether individuals exhibit similar responses to three different drugs from different classes. This study used a within-subjects design (total N = 24). All subjects received alcohol, amphetamine and delta-9-tetrahydrocannabinol (THC) in a double-blind, double-dummy fashion. Subjects completed six sessions wherein they received either alcohol, amphetamine, or THC, or corresponding placebos, on separate days. Subjects completed questionnaires about mood, general drug effects, and specific drug effects.

Eligibility

Minimum age: 21 Years. Maximum age: 35 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- English fluency

- High school education

- BMI between 19 and 26

- Individuals who report drinking at least 4 alcoholic drinks on one occasion in the

past month Exclusion Criteria:

- individuals with a medical condition contraindicating study participation, as

determined by our physician

- individuals regularly using any contraindicated medications

- individuals with current dependence on any drug or past dependence on alcohol,

marijuana or stimulants

- individuals with a past year DSM-IV Axis I mood, anxiety, eating, or psychotic

disorder

- women who are pregnant, nursing, or planning to become pregnant in the next 3 months

- individuals who drink more than 10 alcoholic drinks per week

- individuals who currently use i) any illicit drug weekly or more frequently, ii)

stimulant prescription drugs, iii) more than 10 cigarettes per week, and iv) more than 3 cups of coffee per day

Locations and Contacts

Additional Information

Starting date: July 2013
Last updated: June 29, 2015

Page last updated: August 23, 2015

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