Effect of Esmolol on Pain Due to Rocuronium
Information source: Etlik Zubeyde Hanim Womens' Health and Teaching Hospital
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Injection Site Irritation
Intervention: Lidocaine (Drug); Esmolol (Drug); rocuronium (Drug); Placebo (Drug)
Phase: Phase 4
Status: Not yet recruiting
Sponsored by: Etlik Zubeyde Hanim Womens' Health and Teaching Hospital Official(s) and/or principal investigator(s): Fakelma 05327079113, Principal Investigator, Affiliation: Diskapi Teaching and Research Hospital
Overall contact: fatma k. akelma, Phone: 905327079113, Email: fatmakavak@yahoo.com
Summary
90 American society of anesthesiology (ASA) physical status I and II patients undergoing
general anesthesia for elective surgery will be included in the study. Patients will be
randomized into three groups. Group E will receive esmolol (1 mg/kg), Group IL lidocaine
(1. 5 mg/kg)and Group C placebo(NaCl 0. 9%, 5 mL), followed by a 0. 05 mg/kg rocuronium. After
intravenous induction with propofol, adequate muscle relaxation for intubation will be
received by 0. 5 mg/kg rocuronium.
Clinical Details
Official title: The Effect of Esmolol on Pain Due to Rocuronium Injection Pain
Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Supportive Care
Primary outcome: The injection pain due to rocuronium
Secondary outcome: Score on pain due to injection of rocuronium
Detailed description:
Patients will be observed after injection of rocuronium 0. 05mg/kg, then immediately asked if
they have pain in the arm. The response are assessed; discomfort, pain, and withdrawal of
the hand are recorded and graded using a 4-point scale (none, mild, moderate, or severe).
After the intubating dose of rocuronium, withdrawal reactions are scored as follows: (a) no
pain response, (b)pain limited to the wrist, (c) pain limited to the elbow/shoulder, or (d)
generalized pain response.
Eligibility
Minimum age: 18 Years.
Maximum age: 70 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- ASA physical status I and II patients
- Undergoing general anesthesia for elective surgery
Exclusion Criteria:
- Known allergy to esmolol or lidocaine
- Chronic pain
- Pregnancy
- Withdrawal of consent by the patient
Locations and Contacts
fatma k. akelma, Phone: 905327079113, Email: fatmakavak@yahoo.com
Diskapi Teaching and Research Hospital, Ankara, Altindag, Turkey
Additional Information
Starting date: April 2013
Last updated: April 4, 2013
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