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Effect of Esmolol on Pain Due to Rocuronium

Information source: Etlik Zubeyde Hanim Womens' Health and Teaching Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Injection Site Irritation

Intervention: Lidocaine (Drug); Esmolol (Drug); rocuronium (Drug); Placebo (Drug)

Phase: Phase 4

Status: Not yet recruiting

Sponsored by: Etlik Zubeyde Hanim Womens' Health and Teaching Hospital

Official(s) and/or principal investigator(s):
Fakelma 05327079113, Principal Investigator, Affiliation: Diskapi Teaching and Research Hospital

Overall contact:
fatma k. akelma, Phone: 905327079113, Email: fatmakavak@yahoo.com

Summary

90 American society of anesthesiology (ASA) physical status I and II patients undergoing general anesthesia for elective surgery will be included in the study. Patients will be randomized into three groups. Group E will receive esmolol (1 mg/kg), Group IL lidocaine (1. 5 mg/kg)and Group C placebo(NaCl 0. 9%, 5 mL), followed by a 0. 05 mg/kg rocuronium. After intravenous induction with propofol, adequate muscle relaxation for intubation will be received by 0. 5 mg/kg rocuronium.

Clinical Details

Official title: The Effect of Esmolol on Pain Due to Rocuronium Injection Pain

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Supportive Care

Primary outcome: The injection pain due to rocuronium

Secondary outcome: Score on pain due to injection of rocuronium

Detailed description: Patients will be observed after injection of rocuronium 0. 05mg/kg, then immediately asked if they have pain in the arm. The response are assessed; discomfort, pain, and withdrawal of the hand are recorded and graded using a 4-point scale (none, mild, moderate, or severe). After the intubating dose of rocuronium, withdrawal reactions are scored as follows: (a) no pain response, (b)pain limited to the wrist, (c) pain limited to the elbow/shoulder, or (d) generalized pain response.

Eligibility

Minimum age: 18 Years. Maximum age: 70 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- ASA physical status I and II patients

- Undergoing general anesthesia for elective surgery

Exclusion Criteria:

- Known allergy to esmolol or lidocaine

- Chronic pain

- Pregnancy

- Withdrawal of consent by the patient

Locations and Contacts

fatma k. akelma, Phone: 905327079113, Email: fatmakavak@yahoo.com

Diskapi Teaching and Research Hospital, Ankara, Altindag, Turkey
Additional Information

Starting date: April 2013
Last updated: April 4, 2013

Page last updated: August 23, 2015

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