A study in healthy volunteers comparing two different liquid formulations of solifenacin
with each other and with the tablet formulation.
Inclusion Criteria:
- Subject weighs at least 45 kg, and has a body mass index of 18 to 32 kg/m2
- Subject has a normal 12-lead electrocardiogram (ECG)
- Subject, if female, must be at least 2 years postmenopausal, surgically sterile, or
practicing effective birth control, and is not pregnant or lactating
- Subject has good venous access
Exclusion Criteria:
- The subject has a history of any clinically significant disease or malignancy with
the exception of non-melanoma skin cancer
- The subject has a history of or currently has evidence of urinary retention, gastric
retention, or uncontrolled narrow-angle-glaucoma
- The subject has a history of unexplained syncope, cardiac arrest, unexplained cardiac
arrhythmia or torsade de pointes, structural heart disease, or family history of Long
QT syndrome (suggested by sudden death of a close relative at a young age due to
possible or probable cardiac causes)
- The subject has a known hypersensitivity to VESIcare® or any of the excipients in the
formulations, or the subject has a history of severe allergic or anaphylactic
reactions
- The subject has a history of consuming more than 15 units of alcoholic beverages per
week, or has a history of alcoholism or substance abuse within the past two years
prior to screening (Note: one unit = 12 ounces of beer, 4 ounces of wine, or 1 ounce
of spirits)
- The subject has used tobacco containing products or nicotine containing products
within past six months
- The subject has a supine mean systolic blood pressure < 90 or > 160 mmHg and a mean
diastolic blood pressure < 50 or > 90 mmHg, or pulse rate < 40 or >100 beats per
minute
- The subject is known to be positive for human immunodeficiency virus antibody
- The subject has a positive test for hepatitis C antibody or hepatitis B antigen
- The subject's laboratory test results are outside the normal limits and considered
to be clinically significant
- The subject has had treatment with prescription or non-prescription drugs, including
complementary and alternative medicines or over-the-counter medications, with the
exception of hormonal contraceptives, hormone replacement therapy, and occasional use
of acetaminophen within 14 days prior to inclusion into the study
- The subject anticipates an inability to abstain from alcohol or caffeine use
throughout the duration of the study or from grapefruit, Seville oranges, star fruit,
or any products containing these items from throughout the duration of the study
- The subject has received an experimental agent within past 30 days or ten half-lives,
whichever is longer
- The subject has had any significant blood loss
- The subject has any clinically significant history of gastrointestinal symptoms such
as nausea, abdominal discomfort or upset, or heartburn in the four weeks prior to
clinic admission, or a history of any gastrointestinal surgery except for
appendectomy or cholecystectomy
