DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Carboplatin and Paclitaxel With or Without Bevacizumab Compared to Docetaxel, Carboplatin, and Paclitaxel in Treating Patients With Stage II, Stage III, or Stage IV Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cavity Carcinoma (Cancer)

Information source: National Cancer Institute (NCI)
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Brenner Tumor; Fallopian Tube Cancer; Ovarian Carcinosarcoma; Ovarian Clear Cell Cystadenocarcinoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Mixed Epithelial Carcinoma; Ovarian Mucinous Cystadenocarcinoma; Ovarian Serous Cystadenocarcinoma; Ovarian Undifferentiated Adenocarcinoma; Primary Peritoneal Cavity Cancer; Stage II Ovarian Epithelial Cancer; Stage III Ovarian Epithelial Cancer; Stage IV Ovarian Epithelial Cancer

Intervention: carboplatin (Drug); paclitaxel (Drug); docetaxel (Drug); bevacizumab (Biological)

Phase: Phase 1

Status: Completed

Sponsored by: National Cancer Institute (NCI)

Official(s) and/or principal investigator(s):
Joan Walker, Principal Investigator, Affiliation: Gynecologic Oncology Group

Summary

This phase I trial is studying the side effects and best dose of intraperitoneal infusions of carboplatin when given together with intravenous infusions of either docetaxel or paclitaxel followed by intraperitoneal paclitaxel in treating patients with stage II, stage III, or stage IV ovarian epithelial, fallopian tube, or primary peritoneal cavity carcinoma (cancer). Drugs used in chemotherapy, such as carboplatin, docetaxel, and paclitaxel, work in different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and giving them in different ways may kill more tumor cells

Clinical Details

Official title: A Phase I Trial of Intravenous Paclitaxel, Intraperitoneal Carboplatin and Intraperitoneal Paclitaxel or Intravenous Docetaxel, Intraperitoneal Carboplatin and Intraperitoneal Paclitaxel or Intravenous Paclitaxel, Intraperitoneal Carboplatin, Intraperitoneal Paclitaxel and CTEP-Supplied Agent Bevacizumab (NSC 704865, IND 7921) in Patients With Previously Untreated Ovarian, Fallopian Tube or Primary Peritoneal Carcinoma

Study design: Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome:

Maximum tolerated dose (MTD) of IV paclitaxel with IP carboplatin followed by IP paclitaxel, determined according to dose-limiting toxicities (DLTs) graded using Common Terminology Criteria for Adverse Events version 3.0 (CTCAE v3.0)

MTD of IV docetaxel with IP carboplatin followed by IP paclitaxel, determined according to dose-limiting toxicities (DLTs) graded using CTCAE v3.0

MTD of IV paclitaxel with IP carboplatin and IV bevacizumab followed by IP paclitaxel, determined according to dose-limiting toxicities (DLTs) graded using CTCAE v3.0

Secondary outcome:

Incidence of adverse events in patients given IV paclitaxel with IP carboplatin followed by IP paclitaxel at the MTD, assessed by CTCAE v3.0

Incidence of adverse events in patients given of IV docetaxel with IP carboplatin followed by IP paclitaxel at the MTD, assessed by CTCAE v3.0

Incidence of adverse events in patients given IV paclitaxel with IP carboplatin and IV bevacizumab followed by IP paclitaxel at the MTD, assessed by CTCAE v3.0

Detailed description: OBJECTIVES: I. Determine the maximum tolerated dose (MTD) of intraperitoneal (IP) carboplatin when given in combination with IV paclitaxel followed by IP paclitaxel in patients with stage III or IV ovarian epithelial, fallopian tube, or primary peritoneal cavity carcinoma. II. Determine the MTD of IP carboplatin and IV docetaxel when given in combination with IP paclitaxel in these patients. III. To determine the feasibility of the combination of IV paclitaxel, IP carboplatin and IV bevacizumab on day one followed by IP paclitaxel on day eight (Part C Only). IV. Determine the dose-limiting toxic effects and complications in patients treated with these regimens. V. Evaluate the neurotoxicity of this regimen at each cycle using the FACT/GOG-NTX4 assessment tool to determine dose reduction in these patients. VI. Evaluate the techniques used for intraperitoneal catheter placement, surgical procedures, and reporting of outcomes in these patients. OUTLINE: This is a multicenter, dose-escalation study of intraperitoneal (IP) carboplatin. Patients in the dose-escalation phase are not eligible to enter the feasibility phase. DOSE-ESCALATION PHASE (PART A or PART B): Patients receive IP carboplatin on day 1, and paclitaxel IV over 3 hour (part A) or docetaxel IV over 1 hour (Part B) on day 1, and IP paclitaxel on day 8. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity. FEASIBILITY PHASE (PART C): Patients receive IP carboplatin on day 1, paclitaxel IV on day 1, and IP paclitaxel on day 8 in course 1 as in part A dose-escalation phase. Beginning in course 2 and all subsequent courses, patients receive IP carboplatin on day 1, IV paclitaxel on day 1, and IP paclitaxel on day 8 as in the dose-escalation phase, and bevacizumab IV over 30-90 minutes on day 1. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity. Patients are followed every 3 months for 1 year.

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Female.

Criteria:

Inclusion Criteria:

- Histologically confirmed fallopian tube, ovarian epithelial, or primary peritoneal

carcinoma

- Stage II-IV disease

- The following epithelial cell types are allowed:

- Carcinosarcoma

- Serous adenocarcinoma

- Endometrioid adenocarcinoma

- Mucinous adenocarcinoma

- Undifferentiated carcinoma

- Clear cell adenocarcinoma

- Mixed epithelial carcinoma

- Transitional cell carcinoma

- Malignant Brenner's tumor

- Adenocarcinoma not otherwise specified

- Must have undergone prior surgery for ovarian or peritoneal carcinoma within the past

12 weeks

- Optimal (≤ 1 cm residual disease) or suboptimal residual disease following

initial surgery

- Must have a procedure for determining diagnosis of ovarian/peritoneal carcinoma

with appropriate tissue for histologic evaluation

- Synchronous primary endometrial cancer or prior endometrial cancer allowed provided

the following criteria are met:

- Stage ≤ IB

- Less than 3 mm invasion without vascular or lymphatic invasion

- No poorly differentiated subtypes (e. g., grade 3, clear cell, or papillary

serous)

- No epithelial ovarian carcinoma of low malignant potential (borderline carcinomas)

- No CNS disease (e. g., seizures not controlled with standard medical therapy) or

metastasis

- GOG performance status 0-2

- Absolute neutrophil count ≥ 1,500/mm^3

- Platelet count ≥ 100,000/mm^3

- INR ≤ 1. 5 (or an in-range INR, usually between 2 and 3, if a patient is on a stable

dose of therapeutic warfarin for management of venous thrombosis including pulmonary thrombo-embolus) (applies to part C only)

- PTT < 1. 2 times the upper limit of normal (applies to part C only)

- SGOT ≤ 2. 5 times normal

- Alkaline phosphatase ≤ 2. 5 times normal

- Bilirubin ≤ 1. 5 times normal

- Creatinine ≤ 1. 5 times normal

- No active bleeding

- Abnormal cardiac conduction (e. g., bundle branch block or heart block) allowed

provided disease has remained stable for the past 6 months

- No unstable angina or myocardial infarction within the past 6 months

- No neuropathy (sensory and motor) > CTCAE grade 1

- Not pregnant or nursing

- Fertile patients must use effective contraception during and for at least 6 months

after completion of study therapy

- No septicemia, severe infection, or acute hepatitis

- No other invasive malignancy within the past 5 years except non-melanoma skin cancer

or localized breast cancer

- No circumstance that would preclude study participation

- No history of allergic reaction to polysorbate 80 (e. g., etoposide or vitamin E)

- No known hypersensitivity to Chinese hamster ovary cell products or other recombinant

human or humanized antibodies (applies to part C only)

- No clinically significant proteinuria

- Must have urine protein-creatinine ratio (UPCR) < 1

- No serious, non-healing wound, ulcer, or bone fracture (applies to part C only)

- At least 3-6 months since prior abdominal fistula or gastrointestinal perforation and

fully recovered (part C only)

- No history of intra-abdominal abscess within the past 28 days (applies to part C

only)

- No active bleeding or pathologic conditions that carry high risk of bleeding, such as

known bleeding disorder, coagulopathy, or tumor involving major vessels (applies to part C only)

- No history or evidence (upon physical examination) of CNS disease, including primary

brain tumor, seizures not controlled with standard medical therapy, or brain metastases (applies to part C only)

- No history of cerebrovascular accident (CVA, stroke), transient ischemic attack (TIA)

or subarachnoid hemorrhage within six months of the first date of treatment on this study (applies to part C only)

- No significant traumatic injury within 28 days (applies to part C only)

- No clinically significant cardiovascular disease, including any of the following

(applies to part C only):

- Uncontrolled hypertension, defined as systolic BP > 150 mm Hg or diastolic BP >

90 mm Hg

- Myocardial infarction or unstable angina < 6 months prior to registration

- New York Heart Association (NYHA) Grade II or greater congestive heart failure

- Serious cardiac arrhythmia requiring medication

- CTCAE Grade 2 or greater peripheral vascular disease (at least brief (< 24 hrs)

episodes of ischemia managed non-surgically and without permanent deficit)

- History of CVA within the past six months

- No clinical symptoms or signs of gastrointestinal obstruction and who require

parenteral hydration and/or nutrition (applies to part C only)

- No prior therapy with any anti-VEGF drug, including bevacizumab (applies to part C

only)

- No prior chemotherapy

- Prior adjuvant chemotherapy for localized breast cancer allowed provided the

therapy was completed at least 3 years before registration to study and the patient remains free of recurrent or metastatic disease

- No prior radiotherapy

- No prior cancer therapy that would contraindicate study treatment

- No anticipation of invasive procedures, including any of the following (applies to

part C only):

- Major surgical procedure or open biopsy within 28 days prior to the first date

of bevacizumab therapy (cycle 2)

- Major surgical procedure anticipated during the course of the study

- Core biopsy within 7 days prior to the first date of bevacizumab therapy

Locations and Contacts

University of California Medical Center At Irvine-Orange Campus, Orange, California 92868, United States

Colorado Gynecologic Oncology Group, Aurora, Colorado 80010, United States

University of Chicago Comprehensive Cancer Center, Chicago, Illinois 60637-1470, United States

University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, United States

Greater Baltimore Medical Center, Baltimore, Maryland 21204, United States

Johns Hopkins University, Baltimore, Maryland 21287-8936, United States

Washington University School of Medicine, Saint Louis, Missouri 63110, United States

Cooper Hospital University Medical Center, Camden, New Jersey 08103, United States

Case Western Reserve University, Cleveland, Ohio 44106, United States

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland, Ohio 44111, United States

Lake University Ireland Cancer Center, Mentor, Ohio 44060, United States

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, United States

Cancer Care Associates-Midtown, Tulsa, Oklahoma 74104, United States

Cancer Care Associates-Yale, Tulsa, Oklahoma 74136-1929, United States

Gynecologic Oncology Group, Philadelphia, Pennsylvania 19103, United States

Women and Infants Hospital, Providence, Rhode Island 02905, United States

Additional Information

Starting date: May 2004
Last updated: March 18, 2013

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017