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Predict Antidepressant Responsiveness Using Pharmacogenomics

Information source: Samsung Medical Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Depression; Depressive Symptoms

Intervention: SSRI treated group (Drug); non-SSRI treated group (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: Samsung Medical Center

Official(s) and/or principal investigator(s):
Doh Kwan Kim, M.D., Ph.D., Principal Investigator, Affiliation: Samsung Medical Center

Overall contact:
JungShil Back, B/Sc., Phone: 82-2-3410-0946, Email: jungshil.back@sbri.co.kr

Summary

The purpose of this study is to determine whether genetic information associated with individual depressive symptoms.

Clinical Details

Official title: Predict Antidepressant Responsiveness Using Pharmacogenomics

Study design: Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Presences of each individual symptom of depression at 1,2,4,6,12 weeks

Detailed description: The primary hypothesis is that the variations of the candidate genes are associated with individual symptoms in patients with depression. The Second hypothesis is that patients with the associated genetic variation suffer longer from the associated symptom than the patients without the associated genetic variation.

Eligibility

Minimum age: 19 Years. Maximum age: 89 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Eligible patients were enrolled in the clinical trials program of hte Samsung Medical

Center Geropsychiatry and Affective Disorder Clinics(Seoul, Korea). They received a semistructured diagnostic interview, the Samsung Psychiatric Evaluation Schedule. The affective disorder section of the Samsung Psychiatric Evaluation Schedule uses the Korean version of the structured clinical interview for the diagnostic and statistical manual of mental disorders, Fourth edition.

- interview with one more patient's family member for objective diagnosis and final

diagnosis decision by agreements of two more psychiatric physicians Exclusion Criteria:

- received psychotropic medication within 2 weeks of the study or fluoxetine within 4

weeks

- potential study participants for pregnancy, significant medical conditions, abnormal

laboratory baseline values, unstable psychiatric features(eg. suicidal), history of alcohol of drug dependence, seizures, head trauma with loss of consciousness, neurological illness, or concomitant Axis I psychiatric disorder.

Locations and Contacts

JungShil Back, B/Sc., Phone: 82-2-3410-0946, Email: jungshil.back@sbri.co.kr

Samsung Medical Center, Kangnam, Seoul, Korea, Republic of; Recruiting
Doh Kwan Kim, MD.PhD, Phone: 82-2-3410-3582, Email: dohkwan.kim@samsung.com
Woojae Myung, MD., Phone: 82-2-3410-6562, Email: smbhealer@gmail.com
Additional Information

Starting date: February 2003
Last updated: June 4, 2015

Page last updated: August 23, 2015

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