This partially randomized, multi-center parallel-group study will evaluate the safety,
pharmacokinetics and the effect on viral load and viral shedding of Tamiflu (Oseltamivir) in
patients with influenza. Adult and adolescent patients will be randomized to receive either
100 mg or 200 mg of study drug intravenously every 12 hours. Investigators and patients are
blinded to knowledge of the assigned dose of Tamiflu. There is an option to convert to oral
Tamiflu after 6 intravenous infusions. The anticipated time on study treatment is 5 days,
with an optional treatment extension of a further 5 days, if necessary. There will be a
non-randomized, open-label treatment group for patients with moderate/severe renal
impairment or renal failure. Intravenous dose levels and frequency will be adjusted
appropriately to their renal situation.
Minimum age: 13 Years.
Maximum age: N/A.
Gender(s): Both.
Odense C 5000, Denmark
Bron 69677, France
Garches 92380, France
La Tronche 38700, France
Paris 75651, France
Paris 75679, France
Paris 75970, France
Tours 37044, France
Budapest 1097, Hungary
Budapest 1125, Hungary
Debrecen 4012, Hungary
Eger 3300, Hungary
Gyor 9024, Hungary
Gyula 5700, Hungary
Kaposvar 7400, Hungary
Miskolc 3526, Hungary
Nyiregyhaza 4400, Hungary
Pecs 7624, Hungary
Szeged 6725, Hungary
Szolnok 5000, Hungary
Szombathely 9700, Hungary
Veszprem H-8200, Hungary
Genova 16132, Italy
Milano 20157, Italy
Monza 20052, Italy
Pavia 27100, Italy
Roma 00149, Italy
Kaunas 47116, Lithuania
Vilnius 08117, Lithuania
Bialystok 15-540, Poland
Chorzow 41-500, Poland
Radom 26-610, Poland
Warszawa 01-201, Poland
Bucharest 21105, Romania
Constanta 8700, Romania
Craiova 200515, Romania
Timisoara 300310, Romania
Almeria 04009, Spain
Madrid 28905, Spain
Birmingham, Alabama 35233, United States
Montgomery, Alabama 36106, United States
Elche, Alicante 03203, Spain
Phoenix, Arizona 85008, United States
Little Rock, Arkansas 72205, United States
Duarte, California 91010, United States
Los Angeles, California 90027, United States
San Diego, California 92120, United States
Wilmington, Delaware 19803, United States
Melbourne, Florida 32901, United States
Miami, Florida 33126, United States
Pensacola, Florida 32504, United States
South Miami, Florida 33143, United States
Tampa, Florida 33606, United States
Atlanta, Georgia 30309, United States
Chicago, Illinois 60612, United States
Chicago, Illinois 60637, United States
Maywood, Illinois 60153, United States
Des Moines, Iowa 50314, United States
Kansas City, Kansas 64128, United States
Overland Park, Kansas 66211, United States
Wichita, Kansas 67214, United States
Madisonville, Kentucky 42431, United States
New Orleans, Louisiana 70121, United States
Worcester, Massachusetts 01655, United States
Detroit, Michigan 48202, United States
Kalamazoo, Michigan 49007, United States
Duluth, Minnesota 55805, United States
Minneapolis, Minnesota 55454, United States
Jackson, Mississippi 39202, United States
St. Joseph, Missouri 64506, United States
Butte, Montana 59701, United States
Grand Island, Nebraska 68803, United States
Holmdel, New Jersey 07733, United States
Bronx, New York 10467, United States
New York, New York 10007, United States
New York, New York 10032, United States
New York, New York 10065, United States
South Bronx, New York 10461, United States
Stony Brook, New York 11794, United States
Charlotte, North Carolina 28233, United States
Winston-Salem, North Carolina 27103, United States
Akron, Ohio 44304, United States
Cincinnati, Ohio 45229, United States
Cincinnati, Ohio 45267, United States
Cleveland, Ohio 44109, United States
Dayton, Ohio 45404, United States
Youngstown, Ohio 44501, United States
Oklahoma City, Oklahoma 73104, United States
Philadelphia, Pennsylvania 19106, United States
Pittsburgh, Pennsylvania 15213-2582, United States
Dallas, Texas 75216, United States
Dallas, Texas 75235, United States
San Antonio, Texas 78205, United States
San Antonio, Texas 78232, United States
Norfolk, Virginia 23510, United States
Charleston, West Virginia 25304, United States