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Treatment of PTSD by Reduction of Traumatic Memory Reconsolidation by Propranolol : a Multisite Trial

Information source: University Hospital, Toulouse
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Post-traumatic Stress Disorder

Intervention: Propranolol (Drug); Trauma reactivation (Other); placebo (Drug)

Phase: Phase 2

Status: Recruiting

Sponsored by: University Hospital, Toulouse

Official(s) and/or principal investigator(s):
Philippe BIRMES, MD, Principal Investigator, Affiliation: University Hospital, Toulouse

Overall contact:
Philippe BIRMES, MD, Phone: 05 61 77 25 81, Email: birmes.p@chu-toulouse.fr


The purpose of this study is to test whether propranolol, when given during a re-evocation of a traumatic memory, is capable of reducing subsequent PTSD symptoms associated with that memory.

Clinical Details

Official title: Treatment of PTSD by Reduction of Traumatic Memory Reconsolidation by Propranolol : a Multisite Trial

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Primary outcome: PTCD CheckList (PCL) total score.

Detailed description: Post-traumatic stress disorder (PTSD) develops following an exposure to a life threatening event. One of the characteristic features of PTSD is the recurrence of intrusive memories of an experienced trauma. The persistence of disturbing traumatic memories in PTSD is often explained in terms of a trauma-induced enhancement of memory encoding. Several studies indicate that an increased noradrenergic activity during trauma enhances the encoding of memory. Elevated levels of norepinephrine in the cerebrospinal fluid of individuals with PTSD and the correlation of this elevation with the severity of PTSD symptoms suggest that increased noradrenergic activity is also involved in the maintenance of PTSD symptoms. Reactivation of memory by retrieval also renders the memory labile and susceptible to treatments. This latter process is referred to as memory reconsolidation. Consolidation and reconsolidation both occur within a distinct time window following new learning (in consolidation) and/or retrieval (in reconsolidation). Even well-consolidated old fear memories undergo reconsolidation and may be disrupted by means of pharmacological manipulation. Propranolol may be effective in treating PTSD long after symptoms have been consolidated. Propranolol given after reactivation of the memory of a past traumatic event reduces physiologic responding during subsequent mental imagery of the event. HYPOTHESE: Subjects with chronic PTSD who receive propranolol before trauma evocation will subsequently show decreased PTSD symptoms, compared to subjects who receive a placebo. METHOD: 56 participants with chronic PTSD will be recruited for participation. On Week 1, the subjects will complete a standardized measure of PTSD symptoms. Next, 90 minutes after the administration of the study medication (either propranolol or placebo), participants will undergo a script preparation procedure, during which they will disclose details of their traumatic event. Scripts portraying this event will be prepared for subsequent replay. On Week 2, after the administration of the study medication (either propranolol or placebo), participants will be asked (reading the script) to engaged in a script-driven mental imagery of the traumatic event. Following this procedure, PTSD symptoms will be assessed. The same procedure will be repeated on Weeks 3, 4, 5 and 6. On Weeks 7 and 18, the standardized measure of PTSD symptoms will be repeated.


Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.


Inclusion Criteria:

- Diagnosis of chronic PTSD

- PTSD CheckList total score >44

Exclusion Criteria:

- Systolic blood pressure < 100 mmHg

- Contraindication to Propranolol

- Previous adverse reaction to a β-blocker

- Use of another β-blocker

- Use of medication that could involve potentially dangerous interactions with


- Psychotherapy or treatment with any pharmacologic PTSD medication within the 2 weeks

prior to inclusion (6 weeks for fluoxetine)

- Female with reproductive potential without reliable means of contraception

- Pregnancy or lactation

- Alcohol or drug abuse

Locations and Contacts

Philippe BIRMES, MD, Phone: 05 61 77 25 81, Email: birmes.p@chu-toulouse.fr

Centre Hospitalier Charles Perrens, Bordeaux 33076, France; Not yet recruiting
Bruno AOUIZERATE, PHD, Phone: 05-56-56-35-85, Email: bruno.aouizerate@u-bordeaux2.fr
bruno AOUZERATE, PHD, Principal Investigator

Chru Lille, Lille 59037, France; Recruiting
Guillaume VAIVA, PHD, Phone:, Email: gvaiva@chru-lille.fr
Guillaume VAIVA, PHD, Principal Investigator

Chu Montpellier, Montpellier 34295, France; Not yet recruiting
Jérôme ATTAL, PHD, Phone: 04 67 33 97 18, Email: j-attal@chu-montpellier.fr
jerome ATTAL, PHD, Principal Investigator

CHU Toulouse, Toulouse 31000, France; Recruiting
Philippe BIRMES, PHD, Phone: 05 61 77 25 81, Email: birmes.p@chu-toulouse.fr
Philippe BIRMES, PHD, Principal Investigator

Additional Information

Starting date: November 2012
Last updated: June 10, 2015

Page last updated: August 23, 2015

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