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The Effects of Celecoxib on Bone Ingrowth

Information source: University of Utah
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Bone Ingrowth; Pain

Intervention: Celecoxib (Drug)

Phase: N/A

Status: Terminated

Sponsored by: University of Utah

Official(s) and/or principal investigator(s):
Roy Bloebaum, Ph.D., Principal Investigator, Affiliation: Research Professor, Orthopedic Surgery


The purpose of this study is to evaluate the effect of Celebrex on bone growth into porous coated implants, following postoperative total knee arthroplasty administration of Celebrex for pain relief.

Clinical Details

Official title: The Effects of Celecoxib on Bone Ingrowth in Porous Coated Titanium Ceramic Implants in Humans

Study design: Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Basic Science

Primary outcome: Bone Ingrowth

Secondary outcome: Pain Score


Minimum age: 18 Years. Maximum age: 95 Years. Gender(s): Male.


Inclusion Criteria:

- Male VA bilateral TKA patients 18 years or older with primary OA diagnosis

Exclusion Criteria:

- Patients with osteoporosis, hypersensitivity to Celebrex, allergy to tetracycline,

Sulfonamides, patient with asthma, urticaria, or allergic-type reactions to aspirin or NSAIDs.

- Patients who have had CABG.

- Patients with a history of peptic ulcer disease, duodenal ulcers.

- Female patients and patients diagnosed with unstable hypertension or hypotensive,

with serum creative levels above 1. 8-2. 0 or diagnosed with severe renal disease.

Locations and Contacts

Veteran Affairs (VA) Medical Center, Salt Lake City, Utah 84148, United States
Additional Information

Related publications:

Hofmann AA, Bloebaum RD, Rubman MH, Bachus KN, Plaster RL. Microscopic analysis of autograft bone applied at the interface of porous-coated devices in human cancellous bone. Int Orthop. 1992;16(4):349-58.

Hofmann AA, Bloebaum RD, Koller KE, Lahav A. Does celecoxib have an adverse effect on bone remodeling and ingrowth in humans? Clin Orthop Relat Res. 2006 Nov;452:200-4.

Starting date: June 2008
Last updated: December 9, 2014

Page last updated: August 20, 2015

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